Effects of Fe-YM1504 on iron deficiency anemia in rats

doi:10.1039/c6fo00423g

	Effects of Fe-YM1504 on iron deficiency anemia in rats
	Zhang, Xin-Guo; Wei, Guo-Xing; Wang, Wen-Na; Ma, Guo-Di; Tang, Peng; Chen, Xiao-Qian
刊名	FOOD & FUNCTION
	2016
卷号	7 期号:7 页码:3184-3192
ISSN号	2042-6496
DOI	10.1039/c6fo00423g
英文摘要	Iron deficiency anemia (IDA) is one of the most serious forms of malnutrition. It is possible that some strains present in the natural environment possess a higher tolerance to inorganic iron and a higher ability to convert and accumulate iron compared with Saccharomyces cerevisiae wild-type strain. In the present study, the strain no. YM1504, able to grow in an iron-rich environment, was used as a potential organic iron supplement, and its efficacy in alleviating IDA in rats was investigated. Sixty female weanling Sprague-Dawley rats were randomly divided into a normal control group fed with a standard diet and a model group fed with an iron-deficient diet to create the IDA model. After the model was established, IDA rats were further randomly divided into five subgroups: the IDA group, the ferrous sulfate (FeSO4) group and Fe-YM1504 low-, medium-or high-dose groups receiving different concentrations of Fe-YM1504 supplements. Our results showed that Fe-YM1504 has an effective restorative function by returning the hemoglobin (Hb), hematocrit (HCT), mean corpuscular hemoglobin (MCH), mean corpuscular volume (MCV), serum iron (SI), total iron binding capacity (TIBC), serum ferritin (SF), etc. in IDA animals to the normal level. Moreover, malondialdehyde and the enzyme activities of superoxide dismutase and glutathione peroxidase in both plasma and liver homogenate were improved. Finally, compared with the FeSO4 group, the Fe-YM1504 middle-dose was more effective in alleviating IDA and fewer side effects were observed. The present study indicated that iron-enriched strain no. YM1504 might play a significant role in ameliorating IDA rats and might be exploited as a new iron supplement.
资助项目	program of the National Natural Science Foundation of China[31360379] ; Gansu province natural science fund[1308RJZA167]
WOS研究方向	Biochemistry & Molecular Biology ; Food Science & Technology
语种	英语
出版者	ROYAL SOC CHEMISTRY
WOS记录号	WOS:000380098900025
状态	已发表
内容类型	期刊论文
源URL	[http://119.78.100.223/handle/2XXMBERH/33822]
专题	生命科学与工程学院
通讯作者	Zhang, Xin-Guo
作者单位	Lanzhou Univ Technol, Key Lab Screening & Proc New Tibetan Med Gansu Pr, Sch Life Sci & Engn, Lanzhou 730050, Gansu, Peoples R China
推荐引用方式 GB/T 7714	Zhang, Xin-Guo,Wei, Guo-Xing,Wang, Wen-Na,et al. Effects of Fe-YM1504 on iron deficiency anemia in rats[J]. FOOD & FUNCTION,2016,7(7):3184-3192.
APA	Zhang, Xin-Guo,Wei, Guo-Xing,Wang, Wen-Na,Ma, Guo-Di,Tang, Peng,&Chen, Xiao-Qian.(2016).Effects of Fe-YM1504 on iron deficiency anemia in rats.FOOD & FUNCTION,7(7),3184-3192.
MLA	Zhang, Xin-Guo,et al."Effects of Fe-YM1504 on iron deficiency anemia in rats".FOOD & FUNCTION 7.7(2016):3184-3192.