Secondary Metabolites and PI3K Inhibitory Activity of Colletotrichum gloeosporioides, a Fungal Endophyte of Uncaria rhynchophylla

doi:10.1007/s00284-019-01707-7

	Secondary Metabolites and PI3K Inhibitory Activity of Colletotrichum gloeosporioides, a Fungal Endophyte of Uncaria rhynchophylla
	Yang, Zhong-Duo 2; Li, Zhi-Jie 2; Zhao, Jun-Wen 2; Sun, Jian-Hui 2; Yang, Li-Jun 2; Shu, Zong-Mei 1,2
刊名	CURRENT MICROBIOLOGY
	2019-07
卷号	76 期号:7 页码:904-908
ISSN号	0343-8651
DOI	10.1007/s00284-019-01707-7
英文摘要	In the present study, nine compounds (1-9) were isolated from Colletotrichum gloeosporioides (an endophytic fungus from Uncaria rhynchophylla) which was cultured in wheat bran medium. Their structures were elucidated as 4-Epi-14-hydroxy-10, 23-dihydro-24, 25-dehydroaflavinine (1), 10, 23-Dihydro-24,25 -dehydro-21-oxoaflavinine (2), Ergosterol (3), Ergosterol peroxide (4), Mellein (5), 4, 5-dihydroblumenol A (6), Colletotrichine A (7), Cyclo(L-leucyl-L-leucyl) (8), and Brevianamide F (9) based on NMR spectral data, as well as comparing with previous literature data. This is the first report about the isolation of compounds 1-2, 6, and 8-9 from Colletotrichum genus. All compounds were tested for their phosphoinositide 3-kinase (PI3K) inhibitory activity. Compounds 8 and 9 showed potent PI3K inhibitory activity with IC50 values of 38.1 and 4.8 mu M, respectively, while the other compounds showed very weak activity at a concentration of 20 mu g/mL.
资助项目	National Natural Science Foundation of China[21762027]
WOS研究方向	Microbiology
语种	英语
出版者	SPRINGER
WOS记录号	WOS:000469873300016
状态	已发表
内容类型	期刊论文
源URL	[http://119.78.100.223/handle/2XXMBERH/31742]
专题	生命科学与工程学院
通讯作者	Yang, Zhong-Duo
作者单位	1.Lanzhou Univ Technol, Prov Educ Key Lab Screening Evaluat & Adv Proc Tr, Sch Life Sci & Engn, Lanzhou 730050, Gansu, Peoples R China 2.Lanzhou Univ Technol, Sch Life Sci & Engn, 287 Lan Gong Pin Rd,Qi Li He Block, Lanzhou 730050, Gansu, Peoples R China
推荐引用方式 GB/T 7714	Yang, Zhong-Duo,Li, Zhi-Jie,Zhao, Jun-Wen,et al. Secondary Metabolites and PI3K Inhibitory Activity of Colletotrichum gloeosporioides, a Fungal Endophyte of Uncaria rhynchophylla[J]. CURRENT MICROBIOLOGY,2019,76(7):904-908.
APA	Yang, Zhong-Duo,Li, Zhi-Jie,Zhao, Jun-Wen,Sun, Jian-Hui,Yang, Li-Jun,&Shu, Zong-Mei.(2019).Secondary Metabolites and PI3K Inhibitory Activity of Colletotrichum gloeosporioides, a Fungal Endophyte of Uncaria rhynchophylla.CURRENT MICROBIOLOGY,76(7),904-908.
MLA	Yang, Zhong-Duo,et al."Secondary Metabolites and PI3K Inhibitory Activity of Colletotrichum gloeosporioides, a Fungal Endophyte of Uncaria rhynchophylla".CURRENT MICROBIOLOGY 76.7(2019):904-908.