Preparation and Characterization of Polysaccharide-Based Hydrogels for Cutaneous Wound Healing

doi:10.3390/polym14091716

	Preparation and Characterization of Polysaccharide-Based Hydrogels for Cutaneous Wound Healing
	Xue, Hongyan; Sun, Meng; Zhao, Xiaoliang; Wang, Yonggang; Yan, Jinxin; Zhang, Weijie
刊名	POLYMERS
	2022-05-01
卷号	14 期号:9
关键词	hydrogel chitosan Lonicera japonica Thunb polysaccharides Mentha canadensis L polysaccharides wound healing skin defect model
DOI	10.3390/polym14091716
英文摘要	Natural hydrogels are growing in interest as a priority for wound healing. Plant polysaccharides have a variety of biological pharmacological activities, and chitosan hydrogels have proven strong antimicrobial effects, but hydrogels prepared with polysaccharides alone have certain deficiencies. Polysaccharides from flowers of Lonicera japonica Thunb. (LP) and the aerial parts of Mentha canadensis L. (MP) were extracted and oxidized by sodium periodate (NaIO4) and then cross-linked with oxidized-carboxymethylated chitosan (O-CCS) to develop oxidized plant- polysaccharides-chitosan hydrogels (OPHs). SEM observation showed that OPHs had porous interior structures with interconnecting pores. The OPHs showed good swelling, water-retention ability, blood coagulation, cytocompatibility properties, and low cytotoxicity (classed as grade 1 according to United States Pharmacopoeia), which met the requirements for wound dressings. Then the cutaneous wound-healing effect was evaluated in BALB/C mice model, after 7 days treatment, the wound-closure rate of OPHs groups were all greater than 50%, and after 14 days, all were greater than 90%, while the value of the control group was only 72.6%. Of them, OPH-2 and OPH-3 were more favorable to the wound-healing process, as the promotion was more significant. The plant polysaccharides and CS-based hydrogel should be a candidate for cutaneous wound dressings.
WOS研究方向	Polymer Science
语种	英语
出版者	MDPI
WOS记录号	WOS:000794589800001
内容类型	期刊论文
源URL	[http://ir.lut.edu.cn/handle/2XXMBERH/158656]
专题	生命科学与工程学院
作者单位	Lanzhou Univ Technol, Sch Life Sci & Engn, Lanzhou 730050, Peoples R China
推荐引用方式 GB/T 7714	Xue, Hongyan,Sun, Meng,Zhao, Xiaoliang,et al. Preparation and Characterization of Polysaccharide-Based Hydrogels for Cutaneous Wound Healing[J]. POLYMERS,2022,14(9).
APA	Xue, Hongyan,Sun, Meng,Zhao, Xiaoliang,Wang, Yonggang,Yan, Jinxin,&Zhang, Weijie.(2022).Preparation and Characterization of Polysaccharide-Based Hydrogels for Cutaneous Wound Healing.POLYMERS,14(9).
MLA	Xue, Hongyan,et al."Preparation and Characterization of Polysaccharide-Based Hydrogels for Cutaneous Wound Healing".POLYMERS 14.9(2022).