Two new azaphilones from the marine-derived fungus Penicillium sclerotiorum E23Y-1A

doi:10.1016/j.phytol.2021.11.006

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	Two new azaphilones from the marine-derived fungus Penicillium sclerotiorum E23Y-1A
	Wang, Sha 1,2; Zeng, Yanbo 1; Yin, Jianjun 2; Chang, Wenjun 1; Zhao, Xiaoliang 2; Mao, Yu 1,2
刊名	PHYTOCHEMISTRY LETTERS
	2022-02-01
卷号	47 页码:76-80
关键词	Azaphilone Marine-derived fungus Penicillium sclerotiorum Metabolite Anti-inflammatory
ISSN号	1874-3900
DOI	10.1016/j.phytol.2021.11.006
英文摘要	Two new azaphilones, penicilazaphilones F (1) and G (2) together with two known analogs (3 and 4), were isolated from fermentation cultures of the marine-derived fungus Penicillium sclerotiorum E23Y-1A. Their structures were elucidated based on spectroscopic methods, including IR, MS, 1D and 2D NMR, as well as by comparison with published data. The absolute configuration of compound 1 was unambiguously determined using electronic circular dichroism (ECD) calculation. All isolated compounds were evaluated for their anti-inflammatory effects. Compounds 1-4 inhibited the lipopolysaccharide-induced production of nitric oxide (NO) in BV-2 cells, with IC50 values of 31.7 +/- 1.5, 34.5 +/- 1.4, 25.3 +/- 2.2, and 34.8 +/- 1.9 mu M, respectively. In contrast, these compounds showed no obvious cytotoxicity at a concentration of 50.0 mu M.
WOS研究方向	Plant Sciences ; Pharmacology & Pharmacy
语种	英语
出版者	ELSEVIER
WOS记录号	WOS:000800560300004
内容类型	期刊论文
源URL	[http://ir.lut.edu.cn/handle/2XXMBERH/158894]
专题	石油化工学院生命科学与工程学院
作者单位	1.Chinese Acad Trop Agr Sci, Inst Trop Biosci & Biotechnol, Hainan Prov Key Lab Funct Components Res & Utiliz, Haikou 571101, Hainan, Peoples R China 2.Lanzhou Univ Technol, Sch Life Sci & Engn, Lanzhou 730050, Peoples R China;
推荐引用方式 GB/T 7714	Wang, Sha,Zeng, Yanbo,Yin, Jianjun,et al. Two new azaphilones from the marine-derived fungus Penicillium sclerotiorum E23Y-1A[J]. PHYTOCHEMISTRY LETTERS,2022,47:76-80.
APA	Wang, Sha,Zeng, Yanbo,Yin, Jianjun,Chang, Wenjun,Zhao, Xiaoliang,&Mao, Yu.(2022).Two new azaphilones from the marine-derived fungus Penicillium sclerotiorum E23Y-1A.PHYTOCHEMISTRY LETTERS,47,76-80.
MLA	Wang, Sha,et al."Two new azaphilones from the marine-derived fungus Penicillium sclerotiorum E23Y-1A".PHYTOCHEMISTRY LETTERS 47(2022):76-80.