Snakegourd root/Astragalus polysaccharide hydrogel preparation and application in 3D printing

doi:10.1016/j.ijbiomac.2018.10.008

	Snakegourd root/Astragalus polysaccharide hydrogel preparation and application in 3D printing
	Yan, Jinxin 3,4; Wang, Yu 3,4; Zhang, Xuan 1,5; Zhao, Xiaoliang 3,4; Ma, Jianzhong 3,4; Pu, Xiuying 3,4; Wang, Yonggang 3,4; Ran, Fen 2; Wang, Yanling 3,4; Leng, Feifan 3,4
刊名	INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
	2019
卷号	121 页码:309-316
ISSN号	0141-8130
DOI	10.1016/j.ijbiomac.2018.10.008
英文摘要	Hydrogels have good water retention, biocompatibility and biodegradability, so they are well used in the medical industry. Here, we have active polysaccharide exacted from Chinese traditional medicine and carboxymethyl chitosan cross-linked to form hydrogel and characterized them by Scanning electron microscopy, FTIR analysis, swelling, degradation, release and cytotoxicity tests. We printed the composite hydrogel into patches with three different shapes by Hot-Melt extruded 3D printer and studied the effects of different shapes on the release of drug. The results show, under acidic or alkaline conditions, the BSA cumulative release rate of the three hydro gel patches with different shape range from 49% to 89%. Therefore, there is a significant difference in the release between circular, cube and rectangular shape. Through the study, we found that the hydrogels we prepared have excellent potential for future applications in drug delivery system. (C) 2018 Published by Elsevier B.V.
WOS研究方向	Biochemistry & Molecular Biology ; Chemistry ; Polymer Science
语种	英语
出版者	ELSEVIER
WOS记录号	WOS:000452346100037
内容类型	期刊论文
源URL	[http://ir.lut.edu.cn/handle/2XXMBERH/155366]
专题	能源与动力工程学院材料科学与工程学院生命科学与工程学院
作者单位	1.Cent Hosp Taian City, Dept Ophthalmol, Tai An, Shandong, Peoples R China; 2.Lanzhou Univ Technol, Sch Mat Sci & Engn, Lanzhou 730050, Gansu, Peoples R China; 3.Langongping Rd 287, Lanzhou, Gansu, Peoples R China; 4.Lanzhou Univ Technol, Sch Life Sci & Engn, Lanzhou 730050, Gansu, Peoples R China; 5.Shandong Prov Longtan Rd 29th, Linyi, Shandong, Peoples R China
推荐引用方式 GB/T 7714	Yan, Jinxin,Wang, Yu,Zhang, Xuan,et al. Snakegourd root/Astragalus polysaccharide hydrogel preparation and application in 3D printing[J]. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,2019,121:309-316.
APA	Yan, Jinxin.,Wang, Yu.,Zhang, Xuan.,Zhao, Xiaoliang.,Ma, Jianzhong.,...&Zhang, Weijie.(2019).Snakegourd root/Astragalus polysaccharide hydrogel preparation and application in 3D printing.INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,121,309-316.
MLA	Yan, Jinxin,et al."Snakegourd root/Astragalus polysaccharide hydrogel preparation and application in 3D printing".INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES 121(2019):309-316.