Facile solvothermal synthesis of mesostructured Fe3O 4/chitosan nanoparticles as delivery vehicles for pH-responsive drug delivery and magnetic resonance imaging contrast agents

doi:10.1002/asia.201301072

	Facile solvothermal synthesis of mesostructured Fe3O 4/chitosan nanoparticles as delivery vehicles for pH-responsive drug delivery and magnetic resonance imaging contrast agents
	Zhao, Guanghui 1; Wang, Jianzhi 1; Peng, Xiaomen 1; Li, Yanfeng 1; Yuan, Xuemei 2; Ma, Yingxia 2
刊名	Chemistry - An Asian Journal
	2014-02-01
卷号	9 期号:2 页码:546-553
关键词	Automobile manufacture Chlorine compounds Drug delivery Ethylene glycol Magnetic properties Magnetic resonance imaging Metal nanoparticles Nanoparticles Coordination architecture Drug-delivery systems Imaging agent Magnetic resonance imaging contrast agents PH response Solvothermal approach Solvothermal synthesis Surface-modification
ISSN号	18614728
DOI	10.1002/asia.201301072
英文摘要	We report a facile fabrication of a host-metal-guest coordination-bonding system in a mesostructured Fe3O4/chitosan nanoparticle that can act as a pH-responsive drug-delivery system. The mesostructured Fe 3O4/chitosan was synthesized by a solvothermal approach with iron(III) chloride hexahydrate as a precursor, ethylene glycol as a reducing agent, ammonium acetate as a porogen, and chitosan as a surface-modification agent. Subsequently, doxorubicin (DOX), acting as a model drug (guest), was loaded onto the mesostructured Fe3O 4/chitosan nanoparticles, with chitosan acting as a host molecule to form the NH2-ZnII-DOX coordination architecture. The release of DOX can be achieved through the cleavage of coordination bonds that are sensitive to variations in external pH under weakly acidic conditions. The pH-responsive nature of the nanoparticles was confirmed by in vitro releases and cell assay tests. Furthermore, the relaxation efficiency of the nanoparticles as high-performance magnetic resonance imaging contrast agents was also investigated. Experimental results confirm that the synthesized mesostructured Fe3O4/chitosan is a smart nanovehicle for drug delivery owing to both its pH-responsive nature and relaxation efficiency. Copyright © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
WOS研究方向	Chemistry
语种	英语
出版者	John Wiley and Sons Ltd, Southern Gate, Chichester, West Sussex, PO19 8SQ, United Kingdom
WOS记录号	WOS:000331088600022
内容类型	期刊论文
源URL	[http://ir.lut.edu.cn/handle/2XXMBERH/113350]
专题	材料科学与工程学院
作者单位	1.State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou 730000, China; 2.School of Material Science and Engineering, Lanzhou University of Technology, Lanzhou 730050, China
推荐引用方式 GB/T 7714	Zhao, Guanghui,Wang, Jianzhi,Peng, Xiaomen,et al. Facile solvothermal synthesis of mesostructured Fe3O 4/chitosan nanoparticles as delivery vehicles for pH-responsive drug delivery and magnetic resonance imaging contrast agents[J]. Chemistry - An Asian Journal,2014,9(2):546-553.
APA	Zhao, Guanghui,Wang, Jianzhi,Peng, Xiaomen,Li, Yanfeng,Yuan, Xuemei,&Ma, Yingxia.(2014).Facile solvothermal synthesis of mesostructured Fe3O 4/chitosan nanoparticles as delivery vehicles for pH-responsive drug delivery and magnetic resonance imaging contrast agents.Chemistry - An Asian Journal,9(2),546-553.
MLA	Zhao, Guanghui,et al."Facile solvothermal synthesis of mesostructured Fe3O 4/chitosan nanoparticles as delivery vehicles for pH-responsive drug delivery and magnetic resonance imaging contrast agents".Chemistry - An Asian Journal 9.2(2014):546-553.