Synthesized negatively charged macromolecules (NCMs) for the surface modification of anticoagulant membrane biomaterials

doi:10.1016/j.ijbiomac.2013.01.014

	Synthesized negatively charged macromolecules (NCMs) for the surface modification of anticoagulant membrane biomaterials
	Ran, Fen 1,2,3; Nie, Shengqiang 1,2; Yin, Zehua 1,2; Li, Jie 3; Su, Baihai 1; Sun, Shudong 1; Zhao, Changsheng 1,2
刊名	INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
	2013-04
卷号	55 页码:269-275
关键词	Anticoagulant biomaterials Negatively charged macromolecules Polyethersulfone membrane RAFT polymerization Blood compatibility
ISSN号	0141-8130
DOI	10.1016/j.ijbiomac.2013.01.014
英文摘要	A series of negatively charged macromolecules (NCMs) including poly (sulfonated styrene-co-methyl methacrylate) (P(SS-co-MMA)), poly (acrylic acid-co-methyl methacrylate) (P(AA-co-MMA)) and poly (sulfonated styrene-co-acrylic acid-co-methyl methacrylate) (P(SS-co-AA-co-MMA)) are synthesized by reversible addition fragmentation chain transfer (RAFT) polymerization using carboxyl-terminated trithiocarbonate as a RAFT agent. Activated partial thromboplastin time (APTT) tests indicate that the NCMs can retard blood clotting due to the negatively charged groups. The synthesized NCMs can be blended with polyethersulfone (PES) in dimethylacetamide (DMAC) to prepare membranes by means of a liquid-liquid phase separation technique. The prepared membranes were regular and smooth, except P(AA-co-MMA) modified membranes which were crude and rough due to the poor miscibility of AA segment and PES. The NCM modified PES membranes exhibited good anticoagulant ability due to the existence of the large density of the negative charges on the membrane surface, which induced a strong electrostatic repulsion with the negatively charged blood constituents. Therefore, the P(SS-co-AA-co-MMA) was designed and prepared with appropriate proportions of SS, AA and MMA for better membrane performance. The results indicated that the P(SS-co-AA-co-MMA) had potential to improve the anticoagulant property of biomaterials and to be applied in blood purification. (C) 2013 Elsevier B.V. All rights reserved.
资助项目	National Natural Science Foundation of China[50973070][51073105][51173119] ; State Education Ministry of China (Doctoral Program for High Education)[20100181110031]
WOS研究方向	Biochemistry & Molecular Biology ; Chemistry ; Polymer Science
语种	英语
出版者	ELSEVIER SCIENCE BV
WOS记录号	WOS:000316778400038
状态	已发表
内容类型	期刊论文
源URL	[http://119.78.100.223/handle/2XXMBERH/34723]
专题	材料科学与工程学院
通讯作者	Ran, Fen
作者单位	1.Sichuan Univ, State Key Lab Polymer Mat Engn, Coll Polymer Sci & Engn, Chengdu 610065, Peoples R China 2.Sichuan Univ, Natl Engn Res Ctr Biomat, Chengdu 610064, Peoples R China 3.Lanzhou Univ Technol, Sch Mat Sci & Engn, State Key Lab Gansu Adv Nonferrous Met Mat, Lanzhou 730050, Peoples R China
推荐引用方式 GB/T 7714	Ran, Fen,Nie, Shengqiang,Yin, Zehua,et al. Synthesized negatively charged macromolecules (NCMs) for the surface modification of anticoagulant membrane biomaterials[J]. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,2013,55:269-275.
APA	Ran, Fen.,Nie, Shengqiang.,Yin, Zehua.,Li, Jie.,Su, Baihai.,...&Zhao, Changsheng.(2013).Synthesized negatively charged macromolecules (NCMs) for the surface modification of anticoagulant membrane biomaterials.INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,55,269-275.
MLA	Ran, Fen,et al."Synthesized negatively charged macromolecules (NCMs) for the surface modification of anticoagulant membrane biomaterials".INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES 55(2013):269-275.