Hemocompatibility and ultrafiltration performance of surface-functionalized polyethersulfone membrane by blending comb-like amphiphilic block copolymer

doi:10.1016/j.memsci.2014.08.013

	Hemocompatibility and ultrafiltration performance of surface-functionalized polyethersulfone membrane by blending comb-like amphiphilic block copolymer
	Song, Haiming 2; Ran, Fen 2; Fan, Huili 2; Niu, Xiaoqin 1; Kang, Long 2; Zhao, Changsheng 3
刊名	JOURNAL OF MEMBRANE SCIENCE
	2014-12
卷号	471 页码:319-327
关键词	Polyethersulfone membrane Hemocompatibility Amphiphilic copolymer Blood purification
ISSN号	0376-7388
DOI	10.1016/j.memsci.2014.08.013
英文摘要	While polyethersulfone (PES) represents outstanding oxidative, thermal and hydrolytic stability as well as good mechanical and film-forming properties, the hemocompatibility of PES membrane must be dramatically enhanced to reduce injections of anticoagulants during hemoclialysis. In this study, a comblike amphiphilic block copolymer poly (vinyl pyrrolidone)-block-poly (acrylate-gralt-poly (methyl methacrylate))-block-poly-(vinyl pyrrolidone) (PVP-b-P(AE-g-PMMA)-b-PVP) was synthesized via reversible addition-fragmentation chain transfer polymerization and used to modify PES membrane via a liquid-liquid phase separation technique. The surface structure of the modified membrane were characterized by using X-ray photoelectron spectroscopic analysis, Fourier transform infrared and water contact angle measurement The modified PES membrane showed low hemolysis ratio, improved hydrophilicity, suppressed platelet adhesion and prolonged activated partial thromboplastin time. And the modified membranes showed high PBS solution (or water) flux and good protein anti -fouling properties. The dramatic performance enhancement is attributed to its unique surMce architecture, which may be formed by migration and sell assembly of PVP-b-P(AE-g-PMMA)-b-PVP during phase separation. In the surface layer of the modified membrane, PVP chain formed functional brush while PMMA chain embedded in the membrane substrate. The highly branched chains of P(AE-g-PMMA) block endowed the modified membrane with good stability, which has potential to be used in blood purification. (C) 2014 Elsevier B.V. All rights reserved,
资助项目	China Postdoctoral Science Foundation[2014M552509]
WOS研究方向	Engineering ; Polymer Science
语种	英语
出版者	ELSEVIER SCIENCE BV
WOS记录号	WOS:000342626000035
状态	已发表
内容类型	期刊论文
源URL	[http://119.78.100.223/handle/2XXMBERH/34241]
专题	材料科学与工程学院生命科学与工程学院省部共建有色金属先进加工与再利用国家重点实验室
通讯作者	Ran, Fen
作者单位	1.Lanzhou Univ Technol, Coll Life Sci & Engn, Lanzhou 730050, Peoples R China 2.Lanzhou Univ Technol, State Key Lab Gansu Adv Nonferrous Met Mat, Sch Mat Sci & Engn, Lanzhou 730050, Peoples R China 3.Sichuan Univ, Coll Polymer Sci & Engn, State Key Lab Polymer Mat Engn, Chengdu 610065, Peoples R China 4.Univ Birmingham, Birmingham, W Midlands, England
推荐引用方式 GB/T 7714	Song, Haiming,Ran, Fen,Fan, Huili,et al. Hemocompatibility and ultrafiltration performance of surface-functionalized polyethersulfone membrane by blending comb-like amphiphilic block copolymer[J]. JOURNAL OF MEMBRANE SCIENCE,2014,471:319-327.
APA	Song, Haiming,Ran, Fen,Fan, Huili,Niu, Xiaoqin,Kang, Long,&Zhao, Changsheng.(2014).Hemocompatibility and ultrafiltration performance of surface-functionalized polyethersulfone membrane by blending comb-like amphiphilic block copolymer.JOURNAL OF MEMBRANE SCIENCE,471,319-327.
MLA	Song, Haiming,et al."Hemocompatibility and ultrafiltration performance of surface-functionalized polyethersulfone membrane by blending comb-like amphiphilic block copolymer".JOURNAL OF MEMBRANE SCIENCE 471(2014):319-327.