Electrospinning of Fucoidan/Chitosan/Poly(vinyl alcohol) Scaffolds for Vascular Tissue Engineering

doi:10.1007/s12221-017-1197-3

	Electrospinning of Fucoidan/Chitosan/Poly(vinyl alcohol) Scaffolds for Vascular Tissue Engineering
	Zhang, Weijie 1; Zhao, Lei 1; Ma, Jianzhong 1; Wang, Xiaochun 1; Wang, Yonggang 1; Ran, Fen 2; Wang, Yanling 1; Ma, Hui 1; Yu, Shujing 3
刊名	FIBERS AND POLYMERS
	2017-05
卷号	18 期号:5 页码:922-932
关键词	Fucoidan Electrospinning Hemocompatibility Vascular tissue engineering
ISSN号	1229-9197
DOI	10.1007/s12221-017-1197-3
英文摘要	The formation of thrombosis has limited the applications of small diameter vascular in cardiovascular diseases. In order to improve the anticoagulant activities of scaffolds, this study combined fucoidan with CS/PVA and investigated the complete physicochemical and mechanical characterization of the scaffolds to evaluate the feasibility of Fucoidan/CS/PVA scaffolds used in vascular tissue engineering. The SEM graphs show a well defined and interconnected pore structure and the nanofiber diameters are ranging from 341 nm to 482 nm. After immersing in PBS for 5 days, the tensile strength of the crosslinked scaffolds was 722 +/- 38 kPa while the elongation at break was 35.5 +/- 1.6 %. Besides, added with fucoidan, the scafflolds showed lower rate of plate adhesion (14.75 +/- 2.10 %) and markedly prolonged the APTT and TT. Furthermore, owing to the great water uptake ability, sufficient porosity, enhanced drug release and low cytotoxicity, the Fucoidan/CS/PVA scaffolds might be used for vascular tissue engineering with good prospect.
WOS研究方向	Materials Science ; Polymer Science
语种	英语
出版者	KOREAN FIBER SOC
WOS记录号	WOS:000402147600014
状态	已发表
内容类型	期刊论文
源URL	[http://119.78.100.223/handle/2XXMBERH/33285]
专题	生命科学与工程学院材料科学与工程学院
通讯作者	Zhang, Weijie
作者单位	1.Lanzhou Univ Technol, Sch Life Sci & Engn, Lanzhou 730050, Gansu, Peoples R China 2.Lanzhou Univ Technol, Sch Mat Sci & Engn, Lanzhou 730050, Gansu, Peoples R China 3.Wuqiang Cty Hosp, Pathol Dept, Hengshui 053300, Hebei, Peoples R China
推荐引用方式 GB/T 7714	Zhang, Weijie,Zhao, Lei,Ma, Jianzhong,et al. Electrospinning of Fucoidan/Chitosan/Poly(vinyl alcohol) Scaffolds for Vascular Tissue Engineering[J]. FIBERS AND POLYMERS,2017,18(5):922-932.
APA	Zhang, Weijie.,Zhao, Lei.,Ma, Jianzhong.,Wang, Xiaochun.,Wang, Yonggang.,...&Yu, Shujing.(2017).Electrospinning of Fucoidan/Chitosan/Poly(vinyl alcohol) Scaffolds for Vascular Tissue Engineering.FIBERS AND POLYMERS,18(5),922-932.
MLA	Zhang, Weijie,et al."Electrospinning of Fucoidan/Chitosan/Poly(vinyl alcohol) Scaffolds for Vascular Tissue Engineering".FIBERS AND POLYMERS 18.5(2017):922-932.