Characterization of Fe3O4@CS@NMDP magnetic nanoparticles with core-shell structure prepared by chemical cross-linking method

doi:10.1142/S1793604717500564

	Characterization of Fe3O4@CS@NMDP magnetic nanoparticles with core-shell structure prepared by chemical cross-linking method
	Shao, Huiping 1; Qi, Jiangcong 1; Lin, Tao 1; Zhou, Yuling 1; Yu, Fucheng 2
刊名	FUNCTIONAL MATERIALS LETTERS
	2017-10
卷号	10 期号:5
关键词	Fe3O4@CS@NMDP composite nanoparticles core-shell magnetic target delivery
ISSN号	1793-6047
DOI	10.1142/S1793604717500564
英文摘要	The core-shell structure composite magnetic nanoparticles (NPs), Fe3O4@chitosan@nimodipine (Fe3O4@CS@NMDP), were successfully synthesized by a chemical cross-linking method in this paper. NMDP is widely used for cardiovascular and cerebrovascular disease prevention and treatment, while CS is of biocompatibility. The composite particles were characterized by an X-ray diffractometer (XRD), a Fourier transform infrared spectroscopy (FT-IR), a transmission electron microscopy (TEM), a vibrating sample magnetometers (VSM) and a high performance liquid chromatography (HPLC). The results show that the size of the core-shell structure composite particles is ranging from 12 nm to 20 nm and the coating thickness of NMDP is about 2 nm. The saturation magnetization of core-shell composite NPs is 46.7 emu/g, which indicates a good potential application for treating cancer by magnetic target delivery. The release percentage of the NMDP can reach 57.6% in a short time of 20 min in the PBS, and to 100% in a time of 60 min, which indicates the availability of Fe3O4@CS@NMDP composite NPs for targeting delivery treatment.
资助项目	Guangdong Foundation of Research[2014B090901003]
WOS研究方向	Materials Science
语种	英语
出版者	WORLD SCIENTIFIC PUBL CO PTE LTD
WOS记录号	WOS:000413150500006
状态	已发表
内容类型	期刊论文
源URL	[http://119.78.100.223/handle/2XXMBERH/33080]
专题	材料科学与工程学院
通讯作者	Shao, Huiping
作者单位	1.Univ Sci & Technol, Inst Adv Mat & Technol, Beijing 100083, Peoples R China 2.Lanzhou Univ Technol, Sch Mat Sci & Engn, Lanzhou 730050, Gansu, Peoples R China
推荐引用方式 GB/T 7714	Shao, Huiping,Qi, Jiangcong,Lin, Tao,et al. Characterization of Fe3O4@CS@NMDP magnetic nanoparticles with core-shell structure prepared by chemical cross-linking method[J]. FUNCTIONAL MATERIALS LETTERS,2017,10(5).
APA	Shao, Huiping,Qi, Jiangcong,Lin, Tao,Zhou, Yuling,&Yu, Fucheng.(2017).Characterization of Fe3O4@CS@NMDP magnetic nanoparticles with core-shell structure prepared by chemical cross-linking method.FUNCTIONAL MATERIALS LETTERS,10(5).
MLA	Shao, Huiping,et al."Characterization of Fe3O4@CS@NMDP magnetic nanoparticles with core-shell structure prepared by chemical cross-linking method".FUNCTIONAL MATERIALS LETTERS 10.5(2017).