A Gas Chromatography Flame Ionization Detector Method for Rapid Simultaneous Separation and Determination of Six Active Ingredients of Anticold Drug

doi:10.2174/1573412917666210106115211

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	A Gas Chromatography Flame Ionization Detector Method for Rapid Simultaneous Separation and Determination of Six Active Ingredients of Anticold Drug
	Yang, Fatang 1; Du, Xiaoyun 2; Wang, Zhen 1; Dong, Yuming 1
刊名	CURRENT PHARMACEUTICAL ANALYSIS
	2022
卷号	18 期号:1 页码:71-81
关键词	Gas chromatography flame ionization detector active ingredients anti-cold drug sensitivity precision
ISSN号	1573-4129
DOI	10.2174/1573412917666210106115211
英文摘要	Aims: To establish a rapid and simultaneous determination of multiple effective ingredients in anti-cold drugs. Background: Anti-cold drugs are stock medicines at home, and most anti-cold formulations are compound preparations. Although the active ingredients of compound preparations have significant effects on the treatment of colds, the excessive dosage or long-term use can produce a series of adverse reactions, including dependence, liver and kidney function damage, digestive system reaction, blood system damage. Now, there are many mature methods for analyzing the active ingredients of anti-cold drugs. However, these methods may have shortcomings, such as a long analysis time or a small number of analysis components. Objective: Establish a gas chromatography-flame ionization detector method for the simultaneous determination of six active ingredients, including acetaminophen, dextromethorphan hydrobromide, pseudoephedrine hydrochloride, chlorpheniraminc malcate, diphenhydraminc hydrochloride, and caffeine in anti-cold drugs. Methods: After the standard was accurately weighed, dissolved in ethanol, filtered by 0.22 mu m membrane and ultrasonically degassed, the gas chromatograph was used for detection. After the actual sample was removed from the coating, ground and crushed, accurately weighed, dissolved in ethanol, filtered by 0.22 mu m membrane and ultrasonically degassed, the gas chromatograph was used for detection. Results: The six components can be completely separated within 7.0min. This method has good sensitivity, precision, accuracy and recovery rate. Under the optimum testing conditions, the limit of detection was 0.360-2.50 mu g/mL, the limit of quantification was 1.20-8.30gg/mL. The calibration curves showed good linearity (R-2 >= 0.9932) over the investigated concentration range between 1.20 and 400 mu g/mL. The recoveries were 89.2% to 109.2%. The RSD of intra-day precision was less than 1.0%. The RSD of inter-day precision was less than 3.2%. The established method was used to determine the ingredients of three anti-cold drugs on the market, and the results showed that the method can accurately determine the ingredients. Conclusion: The method can quickly and simultaneously determine multiple active ingredients in anti-cold medicines. Compared with the published methods in literature, the proposed method has the advantages of fast, the number of analysis components wide application range, convenience, low cost, etc. It provides a reference method for quality control of active ingredients of anti-cold drugs.
WOS研究方向	Pharmacology & Pharmacy
语种	英语
出版者	BENTHAM SCIENCE PUBL LTD
WOS记录号	WOS:000748921500001
内容类型	期刊论文
源URL	[http://ir.lut.edu.cn/handle/2XXMBERH/154886]
专题	兰州理工大学
作者单位	1.Lanzhou Univ, Sch Pharm, Lanzhou 730000, Peoples R China; 2.Lanzhou Univ Technol, Sch Life Sci & Engn, Lanzhou 730000, Peoples R China
推荐引用方式 GB/T 7714	Yang, Fatang,Du, Xiaoyun,Wang, Zhen,et al. A Gas Chromatography Flame Ionization Detector Method for Rapid Simultaneous Separation and Determination of Six Active Ingredients of Anticold Drug[J]. CURRENT PHARMACEUTICAL ANALYSIS,2022,18(1):71-81.
APA	Yang, Fatang,Du, Xiaoyun,Wang, Zhen,&Dong, Yuming.(2022).A Gas Chromatography Flame Ionization Detector Method for Rapid Simultaneous Separation and Determination of Six Active Ingredients of Anticold Drug.CURRENT PHARMACEUTICAL ANALYSIS,18(1),71-81.
MLA	Yang, Fatang,et al."A Gas Chromatography Flame Ionization Detector Method for Rapid Simultaneous Separation and Determination of Six Active Ingredients of Anticold Drug".CURRENT PHARMACEUTICAL ANALYSIS 18.1(2022):71-81.