The role of the lateral dimension of graphene oxide in the regulation of cellular responses

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	The role of the lateral dimension of graphene oxide in the regulation of cellular responses
	Yue, Hua 1,2; Wei, Wei 1; Yue, Zhanguo 1,2; Wang, Bin 1; Luo, Nana 1,2; Gao, Yongjun 3; Ma, Ding 3; Ma, Guanghui 1; Su, Zhiguo 1
刊名	BIOMATERIALS
	2012-06-01
卷号	33 期号:16 页码:4013-4021
关键词	Carbon Cytokine Cytotoxicity Drug delivery Inflammation
ISSN号	0142-9612
通讯作者	Ma, GH
英文摘要	The nanomaterial graphene oxide (GO) has attracted explosive interests in various areas. However, its performance in biological environments is still largely unknown, particularly with regard to cellular response to GO. Here we separated the GO sheets in different size and systematically investigated size effect of the GO in response to different types of cells. In terms of abilities to internalize GO, enormous discrepancies were observed in the six cell types, with only two phagocytes were found to be capable of internalizing GO. The 2 pm and 350 nm GO greatly differed in lateral dimensions, but equally contributed to the uptake amount in macrophages. Similar amounts of antibody opsonization and active Fc gamma receptor-mediated phagocytosis were demonstrated the cause of this behavior. In comparison with the nanosized GO, the GO in micro-size showed divergent intracellular locations and induced much stronger inflammation responses. Present study provided insight into selective internalization, size-independent uptake, and several other biological behaviors undergone by GO. These findings might help build necessary knowledge for potential incorporation of the unique two-dimensional nanomaterial as a biomedical tool, and for avoiding potential hazards. (c) 2012 Elsevier Ltd. All rights reserved.
WOS标题词	Science & Technology ; Technology
类目[WOS]	Engineering, Biomedical ; Materials Science, Biomaterials
研究领域[WOS]	Engineering ; Materials Science
关键词[WOS]	CARBON NANOTUBES ; DRUG-DELIVERY ; MACROPHAGES ; SIZE ; CYTOTOXICITY ; PROTEINS ; DESIGN ; CELLS ; NANOPARTICLES ; NANOMATERIALS
收录类别	SCI
语种	英语
WOS记录号	WOS:000303096300001
公开日期	2013-10-18
内容类型	期刊论文
版本	出版稿
源URL	[http://ir.ipe.ac.cn/handle/122111/3825]
专题	过程工程研究所_生化工程国家重点实验室
作者单位	1.Chinese Acad Sci, Inst Proc Engn, Natl Key Lab Biochem Engn, Beijing 100190, Peoples R China 2.Chinese Acad Sci, Grad Univ, Beijing 100049, Peoples R China 3.Peking Univ, Coll Chem & Mol Engn, Beijing 100871, Peoples R China
推荐引用方式 GB/T 7714	Yue, Hua,Wei, Wei,Yue, Zhanguo,et al. The role of the lateral dimension of graphene oxide in the regulation of cellular responses[J]. BIOMATERIALS,2012,33(16):4013-4021.
APA	Yue, Hua.,Wei, Wei.,Yue, Zhanguo.,Wang, Bin.,Luo, Nana.,...&Su, Zhiguo.(2012).The role of the lateral dimension of graphene oxide in the regulation of cellular responses.BIOMATERIALS,33(16),4013-4021.
MLA	Yue, Hua,et al."The role of the lateral dimension of graphene oxide in the regulation of cellular responses".BIOMATERIALS 33.16(2012):4013-4021.