Antimicrobial and Antitumor Activities of Crude Extracts and Isolated Compounds from Euphorbia humifusa

CORC > 新疆理化技术研究所 > 中国科学院新疆理化技术研究所 > 省部共建新疆特有药用资源利用重点实验室

	Antimicrobial and Antitumor Activities of Crude Extracts and Isolated Compounds from Euphorbia humifusa
	Lin Jianbo; Zhao Haiqing; Hang Ba; Aisa Haji Akber
刊名	ASIAN JOURNAL OF CHEMISTRY
	2013
卷号	25 期号:7 页码:3957-3960
关键词	Euphorbia humifusa Ethyl acetate extract Antimicrobial activity Antitumor activity
ISSN号	0970-7077
通讯作者	Aisa, HA
中文摘要	Euphorbia humifusa Willd. has been used in traditional Chinese medicine. Herein we report the isolation of its constituents and the testing results of their antimicrobial and antitumor activities. The results show that the crude petroleum ether, chloroform, ethyl acetate, butanol and residual methanol fractions exert such activities. Particularly, the crude petroleum ether and ethyl acetate fractions exhibit antigrowth activity against Staphyloccocus aureus with MIC 0.5 mg/mL. Petroleum ether and chloroform fractions significantly exhibit potent antigrowth activity against Caco-2 cells, with IC50 value of 0.059 and 0.025 mg/mL, respectively. The promising bioactivities of the crude petroleum ether fractions guided the first isolation of compounds: 24-methylene cycloartanone (2), dibutyl phthalate (3), hexacosanol (4) and bis-(2-ethylhexyl) phthalate (5) from this species. The antimicrobial activities of compounds 1-2 were evaluated. The tested compounds exhibit potent antigrowth activity against Staphyloccocus aureus, Escherichia coli and Canidia albicans.
学科主题	Chemistry
收录类别	SCI
资助信息	China National Funds for Distinguished Young Scientists 30925045; CAS/SAFEA International Partnership Program for Creative Research Teams
公开日期	2013-11-07
内容类型	期刊论文
源URL	[http://ir.xjipc.cas.cn/handle/365002/2646]
专题	新疆理化技术研究所_省部共建新疆特有药用资源利用重点实验室新疆理化技术研究所_资源化学研究室
作者单位	Chinese Acad Sci, Key Lab Chem Plant Resources Arid Reg, Xinjiang Tech Inst Phys & Chem, Urumqi, Peoples R China
推荐引用方式 GB/T 7714	Lin Jianbo,Zhao Haiqing,Hang Ba,et al. Antimicrobial and Antitumor Activities of Crude Extracts and Isolated Compounds from Euphorbia humifusa[J]. ASIAN JOURNAL OF CHEMISTRY,2013,25(7):3957-3960.
APA	Lin Jianbo,Zhao Haiqing,Hang Ba,&Aisa Haji Akber.(2013).Antimicrobial and Antitumor Activities of Crude Extracts and Isolated Compounds from Euphorbia humifusa.ASIAN JOURNAL OF CHEMISTRY,25(7),3957-3960.
MLA	Lin Jianbo,et al."Antimicrobial and Antitumor Activities of Crude Extracts and Isolated Compounds from Euphorbia humifusa".ASIAN JOURNAL OF CHEMISTRY 25.7(2013):3957-3960.