Synthesis of Substituted Thieno [2,3-d]pyrimidin-4-ones and Their Testing for Evaluation of Cytotoxic Activity on Mammalian Cell Models

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	Synthesis of Substituted Thieno [2,3-d]pyrimidin-4-ones and Their Testing for Evaluation of Cytotoxic Activity on Mammalian Cell Models
	Bozorov Kh A.; Mamadalieva N. Z.; Elmuradov B. Zh; Triggiani D.; Egamberdieva D.; Tiezzi A.; Aisa H. A.; Shakhidoyatov Kh M.
刊名	JOURNAL OF CHEMISTRY
	2013
卷号	2013 期号:1
ISSN号	2090-9063
中文摘要	From 2-amino-3-ethoxycarbonyl-4,5-dimethyl-, -polymethylenethiopenes (1-4) were synthesized 2,3-disubstituted thieno [2,3-d]dihydropyrrolo-, tetrahydropyrido-, and tetrahydroazepino[1,2-a]pyrimidin-4-ones (5-16) for pharmacological investigations. The 12 compounds (5-16) were individually evaluated for their antiproliferative activities on mammalian cancer cell models. All tested compounds showed weak affection on human cervix adenocarcinoma cells (HeLa) whereas some of the tested compounds exhibited more consistent inhibition of cell growth on murine myeloma cells (P3X). In both cases some compounds enhanced cell proliferation.
学科主题	Chemistry
收录类别	SCI
资助信息	Academy of Sciences of the Republic of Uzbekistan FA-F3-T047; National Natural Science Foundation of China 31110103908
公开日期	2013-11-07
内容类型	期刊论文
源URL	[http://ir.xjipc.cas.cn/handle/365002/2731]
专题	新疆理化技术研究所_省部共建新疆特有药用资源利用重点实验室
作者单位	S Yu Yunusov Inst Chem Plant Subst AS RUz, Tashkent 100170, Uzbekistan;Univ Tuscia, Largo Univ, Lab Plant Cytol & Biotechnol, Dept Innovat Biol Agrofoods & Forests Syst DIBAF, I-01100 Viterbo, Italy;Natl Univ Uzbekistan, Dept Biotechnol & Microbiol, Tashkent 100174, Uzbekistan;Chinese Acad Sci, Xinjiang Tech Inst Phys & Chem, Key Lab Xinjiang Indigenous Med Plants Resource U, Urumqi 830011, Peoples R China
推荐引用方式 GB/T 7714	Bozorov Kh A.,Mamadalieva N. Z.,Elmuradov B. Zh,et al. Synthesis of Substituted Thieno [2,3-d]pyrimidin-4-ones and Their Testing for Evaluation of Cytotoxic Activity on Mammalian Cell Models[J]. JOURNAL OF CHEMISTRY,2013,2013(1).
APA	Bozorov Kh A..,Mamadalieva N. Z..,Elmuradov B. Zh.,Triggiani D..,Egamberdieva D..,...&Shakhidoyatov Kh M..(2013).Synthesis of Substituted Thieno [2,3-d]pyrimidin-4-ones and Their Testing for Evaluation of Cytotoxic Activity on Mammalian Cell Models.JOURNAL OF CHEMISTRY,2013(1).
MLA	Bozorov Kh A.,et al."Synthesis of Substituted Thieno [2,3-d]pyrimidin-4-ones and Their Testing for Evaluation of Cytotoxic Activity on Mammalian Cell Models".JOURNAL OF CHEMISTRY 2013.1(2013).