The GABA system regulates the sparse coding of odors in the mushroom bodies of Drosophila

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	The GABA system regulates the sparse coding of odors in the mushroom bodies of Drosophila
	Lei, ZC ; Chen, K ; Li, H ; Liu, H ; Ge, AK
刊名	BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
	2013
卷号	436 期号:1 页码:35-40
关键词	BODY NEURONS RECEPTORS RDL CORTEX
ISSN号	0006-291X
通讯作者	Ge, AK (reprint author), Chinese Acad Sci, Inst Neurosci, 320 Yue Yang Rd, Shanghai 200031, Peoples R China.,akguo@ion.ac.cn
英文摘要	In the mushroom bodies (MBs) of Drosophila, an analogue of the mammalian olfactory cortex, olfactory stimuli are sparsely encoded by Kenyon cells (KCs) that exhibit a high level of odor selectivity. Sparse coding of olfactory stimuli has significant advantages for maximizing the discrimination power and storage capacity of MBs. The inhibitory gamma-aminobutyric acid (GABA) system is important for regulating information processing in MBs, but its specific role in the sparse coding of odors is unclear. In this study, we investigated the role of the GABA system in the sparse coding of odors using an in vivo calcium imaging strategy, which allowed us to measure the activity of the KC population at single cell resolution while the components of the GABA system were genetically manipulated. We found that the down-regulation of GABA(A) but not GABA(B) receptors in KCs reduced the sparseness of odor representations in the MB, as shown by an increase in the population response probability and decrease in the odor selectivity of single KCs. Furthermore, the down-regulation of GABA synthesis in a pair of large GABAergic neurons innervating the entire MB reduced the sparseness of odor representations in KCs. In conclusion, the sparse coding of odors in MBs is regulated by a pair of GABAergic neurons through the GABA(A) receptors on KCs, thus demonstrating a specific role of the inhibitory GABA system on information processing in the MB. (c) 2013 Elsevier Inc. All rights reserved.
学科主题	Biochemistry & Molecular Biology ; Biophysics
收录类别	SCI
资助信息	973 Program [2011CBA00400]; Natural Science Foundation of China [30921064, 90820008, 31130027]; Strategic Priority Research Program of the Chinese Academy of Sciences [XDB02040100]
语种	英语
公开日期	2013-11-06
内容类型	期刊论文
源URL	[http://ir.sibs.ac.cn/handle/331001/2571]
专题	上海神经科学研究所_神经所(总)
推荐引用方式 GB/T 7714	Lei, ZC,Chen, K,Li, H,et al. The GABA system regulates the sparse coding of odors in the mushroom bodies of Drosophila[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2013,436(1):35-40.
APA	Lei, ZC,Chen, K,Li, H,Liu, H,&Ge, AK.(2013).The GABA system regulates the sparse coding of odors in the mushroom bodies of Drosophila.BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,436(1),35-40.
MLA	Lei, ZC,et al."The GABA system regulates the sparse coding of odors in the mushroom bodies of Drosophila".BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 436.1(2013):35-40.