Antinociceptive and anti-inflammatory activities of ethyl acetate fraction from Zanthoxylum armatum in mice

doi:10.1016/j.fitote.2010.11.004

CORC > 兰州理工大学 > 兰州理工大学

	Antinociceptive and anti-inflammatory activities of ethyl acetate fraction from Zanthoxylum armatum in mice
	Guo, Tao 1,2; Deng, Yun-Xia 1; Xie, Hui 1; Yao, Chun-Yan 1; Cai, Cheng-Cheng 1; Pan, Sheng-li 1; Wang, Yang-Lin 3
刊名	FITOTERAPIA
	2011-04
卷号	82 期号:3 页码:347-351
关键词	Zanthoxylum armatum Antinociception Anti-inflammatory HPLC Lignan
ISSN号	0367-326X
DOI	10.1016/j.fitote.2010.11.004
英文摘要	Zanthoxylum armatum DC. is a traditional Chinese medicine that is prescribed to alleviate pain and treat inflammatory disorders. This species is distributed mainly in the southeast and southwest regions of China. In the present study, we found that ethyl acetate fraction of ethanolic extract of Z. armatum could significantly decrease acetic acid-induced writhing numbers, and suppress formalin induced licking times in the first phase at the highest dose and in the second phase at all tested doses. This observation revealed that Z. armatum extract possessed powerful antinociceptive activity. The mechanisms of the antinociceptive effect might be mainly involved in the periphery inflammatory analgesic. In addition, the ethyl acetate fraction also inhibited xylene-induced ear swelling in a dose-dependent manner in mice. Eight lignans [eudesmin, horsfieldin, fargesin, kobusin, sesamin, asarinin, planispine A. and pinoresinol-di-3,3-dimethylallyl] were identified as major components of the ethyl acetate fraction. Considering related studies reporting the anti-inflammatory activity for the identified lignans, lignan might be responsible for its anti-inflammatory activity. Our results confirm that the traditional use of Z. armatum in the treatment of inflammation and pain is warranted. (c) 2010 Elsevier B.V. All rights reserved.
WOS研究方向	Pharmacology & Pharmacy
语种	英语
出版者	ELSEVIER SCIENCE BV
WOS记录号	WOS:000288354700008
状态	已发表
内容类型	期刊论文
源URL	[http://119.78.100.223/handle/2XXMBERH/35119]
专题	兰州理工大学
通讯作者	Pan, Sheng-li
作者单位	1.Fudan Univ, Sch Pharm, Shanghai 201203, Peoples R China 2.Lanzhou Univ Technol, Sch Life & Engn, Lanzhou 730050, Peoples R China 3.Yumen Oilfield Hosp, Yumen 735019, Gansu, Peoples R China
推荐引用方式 GB/T 7714	Guo, Tao,Deng, Yun-Xia,Xie, Hui,et al. Antinociceptive and anti-inflammatory activities of ethyl acetate fraction from Zanthoxylum armatum in mice[J]. FITOTERAPIA,2011,82(3):347-351.
APA	Guo, Tao.,Deng, Yun-Xia.,Xie, Hui.,Yao, Chun-Yan.,Cai, Cheng-Cheng.,...&Wang, Yang-Lin.(2011).Antinociceptive and anti-inflammatory activities of ethyl acetate fraction from Zanthoxylum armatum in mice.FITOTERAPIA,82(3),347-351.
MLA	Guo, Tao,et al."Antinociceptive and anti-inflammatory activities of ethyl acetate fraction from Zanthoxylum armatum in mice".FITOTERAPIA 82.3(2011):347-351.