Two subtypes of schizophrenia identified by an individual-level atypical pattern of tensor-based morphometric measurement | |
Shi, Weiyang18,19,20; Fan, Lingzhong17,18,19,20; Wang, Haiyan19,20; Liu, Bing15,16; Li, Wen18,19,20; Li, Jin19,20; Cheng, Luqi14,19,20; Chu, Congying19,20; Song, Ming18,19,20; Sui, Jing16 | |
刊名 | CEREBRAL CORTEX |
2022-08-25 | |
页码 | 18 |
关键词 | schizophrenia subtype structural MRI neuroimaging-clinic association analysis neuroimaging-transcription association analysis |
ISSN号 | 1047-3211 |
DOI | 10.1093/cercor/bhac301 |
通讯作者 | Jiang, Tianzi(jiangtz@nlpr.ia.ac.cn) |
英文摘要 | Difficulties in parsing the multiaspect heterogeneity of schizophrenia (SCZ) based on current nosology highlight the need to subtype SCZ using objective biomarkers. Here, utilizing a large-scale multisite SCZ dataset, we identified and validated 2 neuroanatomical subtypes with individual-level abnormal patterns of the tensor-based morphometric measurement. Remarkably, compared with subtype 1, which showed moderate deficits of some subcortical nuclei and an enlarged striatum and cerebellum, subtype 2, which showed cerebellar atrophy and more severe subcortical nuclei atrophy, had a higher subscale score of negative symptoms, which is considered to be a core aspect of SCZ and is associated with functional outcome. Moreover, with the neuroimaging-clinic association analysis, we explored the detailed relationship between the heterogeneity of clinical symptoms and the heterogeneous abnormal neuroanatomical patterns with respect to the 2 subtypes. And the neuroimaging-transcription association analysis highlighted several potential heterogeneous biological factors that may underlie the subtypes. Our work provided an effective framework for investigating the heterogeneity of SCZ from multilevel aspects and may provide new insights for precision psychiatry. |
资助项目 | Chinese Academy of Sciences, Science and Technology Service Network Initiative[KFJ-STS-ZDTP-078] ; National Natural Science Foundation of China[31300934] ; National Natural Science Foundation of China[31620103905] ; Science Frontier Program of the C hinese Academy of Sciences[QYZDJ-SSW-SMC019] ; National Key R&D Program o f China[2017YFA0105203] ; Open Research Fund of the State Key Laboratory of Cognitive Neuro science and Learning[CNLYB2004] |
WOS关键词 | ALZHEIMERS-DISEASE ; NEGATIVE SYMPTOMS ; WHITE-MATTER ; BRAIN ; VOLUME ; HETEROGENEITY ; GRAY ; BIOMARKERS ; OXYTOCIN ; DISORDER |
WOS研究方向 | Neurosciences & Neurology |
语种 | 英语 |
出版者 | OXFORD UNIV PRESS INC |
WOS记录号 | WOS:000844525200001 |
资助机构 | Chinese Academy of Sciences, Science and Technology Service Network Initiative ; National Natural Science Foundation of China ; Science Frontier Program of the C hinese Academy of Sciences ; National Key R&D Program o f China ; Open Research Fund of the State Key Laboratory of Cognitive Neuro science and Learning |
内容类型 | 期刊论文 |
源URL | [http://ir.ia.ac.cn/handle/173211/49888] |
专题 | 自动化研究所_脑网络组研究中心 |
通讯作者 | Jiang, Tianzi |
作者单位 | 1.Chinese Acad Sci, Innovat Acad Artificial Intelligence, Beijing 100190, Peoples R China 2.Res Ctr Augmented Intelligence, Zhejiang Lab, Hangzhou 311100, Peoples R China 3.Peking Univ, Ctr Life Sci, PKU IDG, McGovern Inst Brain Res, Beijing 100191, Peoples R China 4.Xinxiang Med Univ, Dept Psychol, Xinxiang 453002, Henan, Peoples R China 5.Wuhan Univ, Dept Psychiat, Renmin Hosp, Wuhan 430060, Peoples R China 6.Xinxiang Med Univ, Int Joint Res Lab Psychiat & Neurosci Henan, Henan Key Lab Biol Psychiat, Xinxiang 453002, Henan, Peoples R China 7.Xinxiang Med Univ, Henan Mental Hosp, Dept Psychiat, Affiliated Hosp 2, Xinxiang 453002, Henan, Peoples R China 8.Peking Univ, Natl Clin Res Ctr Mental Disorders, Key Lab Mental Hlth, Minist Hlth, Beijing 100191, Peoples R China 9.Peking Univ, Inst Mental Hlth, Peking Univ Sixth Hosp, Beijing 100191, Peoples R China 10.Zhumadian Psychiat Hosp, Zhumadian 463000, Peoples R China |
推荐引用方式 GB/T 7714 | Shi, Weiyang,Fan, Lingzhong,Wang, Haiyan,et al. Two subtypes of schizophrenia identified by an individual-level atypical pattern of tensor-based morphometric measurement[J]. CEREBRAL CORTEX,2022:18. |
APA | Shi, Weiyang.,Fan, Lingzhong.,Wang, Haiyan.,Liu, Bing.,Li, Wen.,...&Jiang, Tianzi.(2022).Two subtypes of schizophrenia identified by an individual-level atypical pattern of tensor-based morphometric measurement.CEREBRAL CORTEX,18. |
MLA | Shi, Weiyang,et al."Two subtypes of schizophrenia identified by an individual-level atypical pattern of tensor-based morphometric measurement".CEREBRAL CORTEX (2022):18. |
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