A tetrahedral DNA nanostructure functionalized paper-based platform for ultrasensitive colorimetric mercury detection

doi:10.1016/j.snb.2022.131830

CORC > 烟台海岸带研究所 > 中国科学院烟台海岸带研究所 > 中科院海岸带环境过程与生态修复重点实验室

	A tetrahedral DNA nanostructure functionalized paper-based platform for ultrasensitive colorimetric mercury detection
	Fu, Xiuli 3; Lin, Hao 3; Qi, Ji 1; Li, Fengling 3; Chen, Yan 2; Li, Bowei 1; Chen, Lingxin 1
刊名	SENSORS AND ACTUATORS B-CHEMICAL
	2022-07-01
卷号	362 页码:7
关键词	Paper-based platform Tetrahedral DNA nanostructure Colorimetric Mercury
DOI	10.1016/j.snb.2022.131830
通讯作者	Chen, Yan(ychen0612@163.com) ; Li, Bowei(bwli@yic.ac.cn) ; Chen, Lingxin(lxchen@yic.ac.cn)
英文摘要	A novel tetrahedral DNA nanostructure (TDN) functionalized paper-based colorimetric sensor was developed for ultrasensitive analysis of mercury ion (Hg2+). On the paper-based platform, TDN was used as scaffold to anchor aptamer to improve the capture efficiency owing to the controllably specific orientation, low steric hindrance effect and well-defined spacing. In the absence of Hg2+, biotinylated aptamer would bind with streptavidinlabeled HRP. Whereas, in the presence of Hg2+, aptamer would preferentially bind to Hg2+ owing to the higher binding constant of T-Hg-T than that of T-A, which consequently leading to the biotinylated aptamer releasing from TDN. After introducing TMB-H2O2 solution, strong variation of color signal could be observed. Therefore, the quantitative analysis of Hg2+ was carried out by using smartphone to monitor the color intensity on paper chip. The proposed strategy exhibits good linearity over a wide range of 10(-13)-10(-7) M with a low detection limit of 30 fM. And this method had been successfully applied in real water samples. Our strategy provided a versatile, low-cost and user-friendly paper-based monitoring platform for rapid and ultrasensitive analysis of heavy metal ions and thus had potential applications in food safety and public health.
WOS关键词	COLD VAPOR GENERATION ; ATOMIC-EMISSION-SPECTROMETRY ; CATHODE GLOW-DISCHARGE ; SPECIATION ANALYSIS ; RAPID DETECTION ; ICP-MS ; HG-II ; PHASE ; GOLD ; APTASENSOR
WOS研究方向	Chemistry ; Electrochemistry ; Instruments & Instrumentation
语种	英语
WOS记录号	WOS:000806675000005
资助机构	National Natural ScienceFoundat i o n of China ; Natural Science Foundation of Shandong Province
内容类型	期刊论文
源URL	[http://ir.yic.ac.cn/handle/133337/31207]
专题	烟台海岸带研究所_中科院海岸带环境过程与生态修复重点实验室
通讯作者	Chen, Yan; Li, Bowei; Chen, Lingxin
作者单位	1.Chinese Acad Sci, Res Ctr Coastal Environm Engn & Technol, Yantai Inst Coastal Zone Res, CAS Key Lab Coastal Environm Proc & Ecol Remediat, Yantai 264003, Peoples R China 2.Shandong Agr & Engn Univ, Sch Resources & Environm Engn, Jinan 250100, Peoples R China 3.Yantai Univ, Sch Chem & Chem Engn, Yantai 264005, Peoples R China
推荐引用方式 GB/T 7714	Fu, Xiuli,Lin, Hao,Qi, Ji,et al. A tetrahedral DNA nanostructure functionalized paper-based platform for ultrasensitive colorimetric mercury detection[J]. SENSORS AND ACTUATORS B-CHEMICAL,2022,362:7.
APA	Fu, Xiuli.,Lin, Hao.,Qi, Ji.,Li, Fengling.,Chen, Yan.,...&Chen, Lingxin.(2022).A tetrahedral DNA nanostructure functionalized paper-based platform for ultrasensitive colorimetric mercury detection.SENSORS AND ACTUATORS B-CHEMICAL,362,7.
MLA	Fu, Xiuli,et al."A tetrahedral DNA nanostructure functionalized paper-based platform for ultrasensitive colorimetric mercury detection".SENSORS AND ACTUATORS B-CHEMICAL 362(2022):7.