Health Risks of Chronic Exposure to Small Doses of Microcystins: AnIntegrative Metabolomic and Biochemical Study of Human Serum br

doi:10.1021/acs.est.2c00973

	Health Risks of Chronic Exposure to Small Doses of Microcystins: AnIntegrative Metabolomic and Biochemical Study of Human Serum br
	He, Jun 9; Chen, Jun 9; Chen, Feng 9; Chen, Liang 8,9; Giesy, John P.4,5,6,7; Guo, Yuming 3; Liang, Gaodao 2; Deng, Xuwei 9; Wang, Wenjing 1; Xie, Ping 8,9
刊名	ENVIRONMENTAL SCIENCE & TECHNOLOGY
	2022-05-17
卷号	56 期号:10 页码:6548-6559
关键词	metabolomics microcystin epidemiological study health risk renal injury
ISSN号	0013-936X
DOI	10.1021/acs.est.2c00973
通讯作者	Xie, Ping(xieping@ihb.ac.cn)
英文摘要	Health risks of chronic exposure to microcystins(MCs), a family of aquatic contaminants produced mainly bycyanobacteria, are critical yet unsolved problems. Despite a fewepidemiological studies, the metabolic profiles of humans exposedto MCs remain unknown, hindering the deep understanding of themolecular toxicity mechanisms. Here, sensitive nuclear magneticresonance (NMR)- and liquid chromatography-mass spectrometry(LC-MS)-based metabolomics were applied to investigate theserum metabolic profiles of humans living near Lake Chao, wheretoxic cyanobacterial blooms occur annually. MCs were positivelydetected in 92 of 144 sera by ultra-high-pressure liquidchromatography-tandem mass spectrometry (UPLC-MS/MS)with a median concentration of 0.016 mu g/L. The estimated dailyintake (0.15-0.27 mu g MC-LReq/day) was less than the tolerable daily intake (TDI, 2.4 mu g MC-LR for 60 kg adults) recommendedby the World Health Organization (WHO). Obvious disruptions of the amino acid metabolism were confirmed and playedimportant roles in renal impairments associated with serum MC burdens. Chronic oral exposure of mice to 30 mu g MC-LR/kg bodymass, which is less than the no observed adverse effect level, also led to obvious renal lesions and metabolic dysfunction. Theseobservations provide thefirst evidence of metabolic disturbance of humans exposed to MCs and indicate that the WHO's TDI valuedetermined traditionally should be lessened to protect human health effectively.
WOS关键词	PRIMARY LIVER-CANCER ; FRESH-WATER ; GLUTATHIONE DETOXIFICATION ; HEPATOTOXIC MICROCYSTINS ; CYANOBACTERIAL TOXINS ; DRINKING-WATER ; UNITED-STATES ; LR ; TOXICITY ; DYNAMICS
WOS研究方向	Engineering ; Environmental Sciences & Ecology
语种	英语
WOS记录号	WOS:000804806300053
内容类型	期刊论文
源URL	[http://ir.yic.ac.cn/handle/133337/31192]
专题	中国科学院烟台海岸带研究所
通讯作者	Xie, Ping
作者单位	1.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Key Lab Coastal Zone Environm Proc, Yantai 264003, Peoples R China 2.Wuhan Ctr Dis Control & Prevent, Wuhan 430072, Peoples R China 3.Monash Univ, Sch Publ Hlth & Prevent Med, Melbourne, Vic 3004, Australia 4.Baylor Univ, Dept Environm Sci, Waco, TX 76706 USA 5.Michigan State Univ, Inst Integrat Toxicol, Zool Dept, E Lansing, MI 48824 USA 6.Univ Saskatchewan, Dept Vet Biomed Sci, Saskatoon, SK S7N 5B4, Canada 7.Univ Saskatchewan, Toxicol Ctr, Saskatoon, SK S7N 5B3, Canada 8.Yunnan Univ, Sch Ecol & Environm Sci, Inst Ecol Res & Pollut Control Plateau Lakes, Kunming 650091, Yunnan, Peoples R China 9.Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Donghu Expt Stn Lake Ecosyst, Wuhan 430072, Peoples R China
推荐引用方式 GB/T 7714	He, Jun,Chen, Jun,Chen, Feng,et al. Health Risks of Chronic Exposure to Small Doses of Microcystins: AnIntegrative Metabolomic and Biochemical Study of Human Serum br[J]. ENVIRONMENTAL SCIENCE & TECHNOLOGY,2022,56(10):6548-6559.
APA	He, Jun.,Chen, Jun.,Chen, Feng.,Chen, Liang.,Giesy, John P..,...&Xie, Ping.(2022).Health Risks of Chronic Exposure to Small Doses of Microcystins: AnIntegrative Metabolomic and Biochemical Study of Human Serum br.ENVIRONMENTAL SCIENCE & TECHNOLOGY,56(10),6548-6559.
MLA	He, Jun,et al."Health Risks of Chronic Exposure to Small Doses of Microcystins: AnIntegrative Metabolomic and Biochemical Study of Human Serum br".ENVIRONMENTAL SCIENCE & TECHNOLOGY 56.10(2022):6548-6559.