Novel Lead Compound Discovery from Aspergillus fumigatus 1T-2against Meloidogyne incognita Based on a Chemical Ecology Study br

doi:10.1021/acs.jafc.1c08147

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	Novel Lead Compound Discovery from Aspergillus fumigatus 1T-2against Meloidogyne incognita Based on a Chemical Ecology Study br
	Wang, Linsong 1,3,4; Qin, Yukun 1,3,4; Fan, Zhaoqian 1,3,4; Gao, Kun 1,3,4; Zhan, Jiang 1,2,3,4; Xing, Ronge 1,3,4; Liu, Song 1,3,4; Li, Pengcheng 1,3,4
刊名	JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
	2022-04-20
卷号	70 期号:15 页码:4644-4657
关键词	Meloidogyne incognita chemical ecology Aspergillus fumigatus 1T-2 2-furoic acid biocontrol
ISSN号	0021-8561
DOI	10.1021/acs.jafc.1c08147
通讯作者	Qin, Yukun(ykqin@qdio.ac.cn) ; Li, Pengcheng(pcli@qdio.ac.cn)
英文摘要	:to replace biohazardous nematicides, there is an ever-increasing need to identify natural product-based agents tocontain root-knot nematodes (RKNs) in agriculture. In this chemical ecology study, an antagonistic fungusAspergillus fumigatus1T-2, which could cause the formation of withering of the gut and vacuole-like structures in the nematode body, was isolated based onthe gradually increased antagonistic interactions between the soil fungi and RKNs. Based on these typical morphologicalcharacteristics, a potent nematode-antagonistic compound 2-furoic acid, which had a simple structure, was successfully identifiedfrom 1T-2 fermentation broth by liquid chromatography-mass spectrometry (LC-MS). 2-Furoic acid showed effective mortalityactivityin vitro, of which the LC50value toMegalaima incognitaat 24 h was 37.75 mu g/mL. 2-Furoic acid had similar mortality activityto the positive control fosthiazate at 30 mu g/mL. Continuous 2-furoic acid exposure had obvious negative influences on bothnematode vitality and egg hatchability. Notably, significant variations were observed in nematodes and eggs with 2-furoic acidtreatment, which might be induced by novel nematocidal mechanisms. Furthermore, the 1T-2 fermentation broth and 2-furoic acidhad significant control efficacy onM. incognitaunder the greenhouse test-tube assay. Overall, thesefindings provide valuable insightsinto the use of 2-furoic acid with biocontrol potential as a preferable lead structure for the development of innovative nematicides
资助项目	National Key R&D Program of China[2019YFD0900705] ; National Natural Science Foundation of China[42076126] ; Shandong Provincial Natural Science Foundation[ZR2020MD072] ; Shandong Provincial Natural Science Foundation Youth Fund[ZR2021QC006] ; Qingdao Science and Technology Demonstration and Guidance Project[20-3-4-22-nsh]
WOS研究方向	Agriculture ; Chemistry ; Food Science & Technology
语种	英语
出版者	AMER CHEMICAL SOC
WOS记录号	WOS:000794068900014
内容类型	期刊论文
源URL	[http://ir.qdio.ac.cn/handle/337002/179290]
专题	海洋研究所_实验海洋生物学重点实验室
通讯作者	Qin, Yukun; Li, Pengcheng
作者单位	1.Pilot Natl Lab Marine Sci & Technol Qingdao, Lab Marine Drugs & Bioprod, Qingdao 266237, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.Chinese Acad Sci, Inst Oceanol, Ctr Ocean Megasci, Shandong Prov Key Lab Expt Marine Biol, Qingdao 266071, Peoples R China 4.Chinese Acad Sci, Inst Oceanol, Ctr Ocean Megasci, CAS, Qingdao 266071, Peoples R China
推荐引用方式 GB/T 7714	Wang, Linsong,Qin, Yukun,Fan, Zhaoqian,et al. Novel Lead Compound Discovery from Aspergillus fumigatus 1T-2against Meloidogyne incognita Based on a Chemical Ecology Study br[J]. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,2022,70(15):4644-4657.
APA	Wang, Linsong.,Qin, Yukun.,Fan, Zhaoqian.,Gao, Kun.,Zhan, Jiang.,...&Li, Pengcheng.(2022).Novel Lead Compound Discovery from Aspergillus fumigatus 1T-2against Meloidogyne incognita Based on a Chemical Ecology Study br.JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,70(15),4644-4657.
MLA	Wang, Linsong,et al."Novel Lead Compound Discovery from Aspergillus fumigatus 1T-2against Meloidogyne incognita Based on a Chemical Ecology Study br".JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY 70.15(2022):4644-4657.