Linked psychopathology-specific factors and individual structural brain abnormalities in schizophrenia
Lin Chai5,6,7; Yaping Wang3,6,7; Weiyang Shi5,6,7; Yu Zhang1; Bing Liu2; Tianzi Jiang3,4,5,6,7; Lingzhong Fan3,4,5,6,7
2022-04
会议日期2022-4
会议地点San Diego, California, United States
英文摘要

Numerous studies havedemonstratedsubstantialinter-individualheterogeneityamongpatientswith schizophrenia, which seriously affects the quantification of diagnosis and treatment schema. As likely causes of schizophrenia include environmentalandgeneticfactors,theseheterogeneities mayreflectvariousmorphologicchangesandclinicalsyndromes among different patients. The normative model is a statistical model offering quantitative measurements of abnormal deviationsunderinterindividualheterogeneity.Meanwhile, exploratoryandconfirmatoryfactorialanalysesof thePositive andNegative SyndromeScale (PANSS) could help propose consistent three-factorstructures to factorizesymptomsinto robust cardinal dimensions. Here, we explored the individual-specific associations among morphologic deviations from normative ranges of brain structure and specific symptomatology structure on three dimensions without general disease effects.Specifically,weemployedanexploratorybi-factormodelforthePANSS scaleandbuiltnormativemodelsfortwo cortical measurements: cortical area and thickness. Significant correlations among different cortical measures and latent symptom groups were observed, which could provide evidence to understand the pathophysiology of schizophrenia symptoms.

内容类型会议论文
源URL[http://ir.ia.ac.cn/handle/173211/48836]  
专题自动化研究所_脑网络组研究中心
作者单位1.Research Center for Healthcare Data Science, Zhejiang Lab, Hangzhou 311100, China
2.State Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, Beijing, 100875, China
3.Sino-Danish Center, University of Chinese Academy of Sciences, Beijing 100190, China
4.CAS Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences, Beijing 100190, China
5.University of Chinese Academy of Sciences, Beijing 100190, China
6.National Laboratory of Pattern Recognition, Institute of Automation, Chinese Academy of Sciences, Beijing 100190, China
7.Brainnetome Center
推荐引用方式
GB/T 7714
Lin Chai,Yaping Wang,Weiyang Shi,et al. Linked psychopathology-specific factors and individual structural brain abnormalities in schizophrenia[C]. 见:. San Diego, California, United States. 2022-4.
个性服务
查看访问统计
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。


©版权所有 ©2017 CSpace - Powered by CSpace