Multimodal Magnetic Resonance Imaging Reveals Aberrant Brain Age Trajectory During Youth in Schizophrenia Patients

doi:10.3389/fnagi.2022.823502

CORC > 自动化研究所 > 中国科学院自动化研究所 > 精密感知与控制研究中心 > 人工智能与机器学习

	Multimodal Magnetic Resonance Imaging Reveals Aberrant Brain Age Trajectory During Youth in Schizophrenia Patients
	Huang, Jiayuan 1,12; Ke, Pengfei 1; Chen, Xiaoyi 1,12; Li, Shijia 1; Zhou, Jing 1; Xiong, Dongsheng 1; Huang, Yuanyuan 2,3; Li, Hehua 2,3; Ning, Yuping 2,3; Duan, Xujun 4
刊名	FRONTIERS IN AGING NEUROSCIENCE
	2022-03-03
卷号	14 页码:11
关键词	schizophrenia accelerated brain aging brain age gap multimodal magnetic resonance imaging machine learning
ISSN号	1663-4365
DOI	10.3389/fnagi.2022.823502
通讯作者	Wu, Fengchun(13580380071@163.com) ; Wu, Kai(kaiwu@scut.edu.cn)
英文摘要	Accelerated brain aging had been widely reported in patients with schizophrenia (SZ). However, brain aging trajectories in SZ patients have not been well-documented using three-modal magnetic resonance imaging (MRI) data. In this study, 138 schizophrenia patients and 205 normal controls aged 20-60 were included and multimodal MRI data were acquired for each individual, including structural MRI, resting state-functional MRI and diffusion tensor imaging. The brain age of each participant was estimated by features extracted from multimodal MRI data using linear multiple regression. The correlation between the brain age gap and chronological age in SZ patients was best fitted by a positive quadratic curve with a peak chronological age of 47.33 years. We used the peak to divide the subjects into a youth group and a middle age group. In the normal controls, brain age matched chronological age well for both the youth and middle age groups, but this was not the case for schizophrenia patients. More importantly, schizophrenia patients exhibited increased brain age in the youth group but not in the middle age group. In this study, we aimed to investigate brain aging trajectories in SZ patients using multimodal MRI data and revealed an aberrant brain age trajectory in young schizophrenia patients, providing new insights into the pathophysiological mechanisms of schizophrenia.
资助项目	National Key Research and Development Program of China[2020YFC2004300] ; National Key Research and Development Program of China[2020YFC2004301] ; National Key Research and Development Program of China[2019YFC0118800] ; National Key Research and Development Program of China[2019YFC0118802] ; National Key Research and Development Program of China[2019YFC0118804] ; National Key Research and Development Program of China[2019YFC0118805] ; National Key Research and Development Program of China[2021YFC2009400] ; National Key Research and Development Program of China[2021YFC2009404] ; National Natural Science Foundation of China[31771074] ; National Natural Science Foundation of China[81802230] ; National Natural Science Foundation of China[72174082] ; Guangdong Basic and Applied Basic Research Foundation Outstanding Youth Project[2021B1515020064] ; Key Research and Development Program of Guangdong[2018B030335001] ; Key Research and Development Program of Guangdong[2020B0101130020] ; Key Research and Development Program of Guangdong[2020B0404010002] ; Science and Technology Program of Guangzhou[201807010064] ; Science and Technology Program of Guangzhou[201803010100] ; Science and Technology Program of Guangzhou[201903010032] ; Science and Technology Program of Guangzhou[202103000032] ; Key Laboratory Program of Guangdong Provincial Education Department[2020KSYS001] ; Open Fund of the Guangdong Provincial Key Laboratory of Physical Activity and Health Promotion[2021B1212040014]
WOS关键词	WHITE-MATTER INTEGRITY ; FUNCTIONAL CONNECTIVITY ; INTERNAL CAPSULE ; TREATMENT-NAIVE ; POSTERIOR LIMB ; DRUG-NAIVE ; 1ST-EPISODE ; ABNORMALITIES ; PREDICTION ; NETWORK
WOS研究方向	Geriatrics & Gerontology ; Neurosciences & Neurology
语种	英语
出版者	FRONTIERS MEDIA SA
WOS记录号	WOS:000784192000001
资助机构	National Key Research and Development Program of China ; National Natural Science Foundation of China ; Guangdong Basic and Applied Basic Research Foundation Outstanding Youth Project ; Key Research and Development Program of Guangdong ; Science and Technology Program of Guangzhou ; Key Laboratory Program of Guangdong Provincial Education Department ; Open Fund of the Guangdong Provincial Key Laboratory of Physical Activity and Health Promotion
内容类型	期刊论文
源URL	[http://ir.ia.ac.cn/handle/173211/48310]
专题	精密感知与控制研究中心_人工智能与机器学习
通讯作者	Wu, Fengchun; Wu, Kai
作者单位	1.South China Univ Technol, Sch Mat Sci & Engn, Dept Biomed Engn, Guangzhou, Peoples R China 2.Guangzhou Med Univ, Guangzhou Huiai Hosp, Affiliated Brain Hosp, Guangzhou, Peoples R China 3.Guangdong Engn Technol Res Ctr Translat Med Menta, Guangzhou, Peoples R China 4.Univ Elect Sci & Technol China, MOE Key Lab Neuroinformat, High Field Magnet Resonance Brain Imaging Key Lab, Chengdu, Peoples R China 5.New Jersey Inst Technol, Dept Biomed Engn, Newark, NJ 07102 USA 6.Chinese Acad Sci, Inst Automat, Beijing, Peoples R China 7.South China Univ Technol, Natl Engn Res Ctr Tissue Restorat & Reconstruct, Guangzhou, Peoples R China 8.South China Univ Technol, Guangdong Prov Key Lab Biomed Engn, Guangzhou, Peoples R China 9.Guangdong Engn Technol Res Ctr Diag & Rehabil Dem, Guangzhou, Peoples R China 10.Guangdong Second Prov Gen Hosp, Inst Healthcare Artificial Intelligence Applicat, Guangzhou, Peoples R China
推荐引用方式 GB/T 7714	Huang, Jiayuan,Ke, Pengfei,Chen, Xiaoyi,et al. Multimodal Magnetic Resonance Imaging Reveals Aberrant Brain Age Trajectory During Youth in Schizophrenia Patients[J]. FRONTIERS IN AGING NEUROSCIENCE,2022,14:11.
APA	Huang, Jiayuan.,Ke, Pengfei.,Chen, Xiaoyi.,Li, Shijia.,Zhou, Jing.,...&Wu, Kai.(2022).Multimodal Magnetic Resonance Imaging Reveals Aberrant Brain Age Trajectory During Youth in Schizophrenia Patients.FRONTIERS IN AGING NEUROSCIENCE,14,11.
MLA	Huang, Jiayuan,et al."Multimodal Magnetic Resonance Imaging Reveals Aberrant Brain Age Trajectory During Youth in Schizophrenia Patients".FRONTIERS IN AGING NEUROSCIENCE 14(2022):11.