Circular RNA VANGL1 Facilitates Migration and Invasion of Papillary Thyroid Cancer by Modulating the miR-194/ZEB1/EMT Axis

doi:10.1155/2022/4818651

	Circular RNA VANGL1 Facilitates Migration and Invasion of Papillary Thyroid Cancer by Modulating the miR-194/ZEB1/EMT Axis
	Xiang, Yangfeng; Wang, Wendong; Gu, Jialei; Shang, Jinbiao
刊名	JOURNAL OF ONCOLOGY
	2022-03-08
卷号	2022
ISSN号	1687-8450
DOI	10.1155/2022/4818651
通讯作者	Shang, Jinbiao(201309020227@stu.sdnu.edu.cn)
英文摘要	Circular RNAs (circRNAs) are often aberrantly expressed in human tumors and also serve a critical regulatory role in papillary thyroid cancer (PTC). The aim of this study is to investigate the expression pattern and biological role of circVANGL1 in PTC. The results revealed that circVANGL1 was significantly upregulated in human PTC samples. In addition, high circVANGL1 expression was closely associated with adverse clinical parameters of PTC patients. Our in vitro experiments further indicated that the knockdown of circVANGL1 using siRNA obviously repressed migration, proliferation, EMT, and invasion of PTC cells, while opposite effects were induced by its overexpression. We further noted that circVANGL1 could interact with miR-194 directly in PTC, and serve as a ceRNA to regulate ZEB1 function. Moreover, miR-194 inhibition markedly abrogated the effects of circVANGL1 knockdown in PTC cells. Therefore, our results provide convincing evidence that circVANGL1 may exert oncogenic effects in PTC, partly via regulating the miR-194/ZEB1 axis.
资助项目	Medical Science Research Program of Zhejiang Province for Youth Talent[2019RC024] ; Applied Research Project of Commonweal Technology in Zhejiang Province[LGF20H160003]
WOS关键词	CELL-PROLIFERATION ; BLADDER-CANCER
WOS研究方向	Oncology
语种	英语
出版者	HINDAWI LTD
WOS记录号	WOS:000779485800003
资助机构	Medical Science Research Program of Zhejiang Province for Youth Talent ; Applied Research Project of Commonweal Technology in Zhejiang Province
内容类型	期刊论文
源URL	[http://ir.hfcas.ac.cn:8080/handle/334002/128577]
专题	中国科学院合肥物质科学研究院
通讯作者	Shang, Jinbiao
作者单位	Chinese Acad Sci, Univ Chinese Acad Sci, Inst Basic Med & Canc IBMC, Dept Head & Neck Surg,Canc Hosp,Zhejiang Canc Hos, Hangzhou 310022, Zhejiang, Peoples R China
推荐引用方式 GB/T 7714	Xiang, Yangfeng,Wang, Wendong,Gu, Jialei,et al. Circular RNA VANGL1 Facilitates Migration and Invasion of Papillary Thyroid Cancer by Modulating the miR-194/ZEB1/EMT Axis[J]. JOURNAL OF ONCOLOGY,2022,2022.
APA	Xiang, Yangfeng,Wang, Wendong,Gu, Jialei,&Shang, Jinbiao.(2022).Circular RNA VANGL1 Facilitates Migration and Invasion of Papillary Thyroid Cancer by Modulating the miR-194/ZEB1/EMT Axis.JOURNAL OF ONCOLOGY,2022.
MLA	Xiang, Yangfeng,et al."Circular RNA VANGL1 Facilitates Migration and Invasion of Papillary Thyroid Cancer by Modulating the miR-194/ZEB1/EMT Axis".JOURNAL OF ONCOLOGY 2022(2022).