A Novel Prognostic Factor TIPE2 in Bladder Cancer

doi:10.3389/pore.2022.1610282

	A Novel Prognostic Factor TIPE2 in Bladder Cancer
	Jiang, Yu 1; Zhang, Zhiqiang 1; Wang, Xian 2; Feng, Zhenzhong 2; Hong, Bo 3; Yu, Dexin 1; Wang, Yi 1,4
刊名	PATHOLOGY & ONCOLOGY RESEARCH
	2022-03-21
卷号	28
关键词	epithelial-mesenchymal transition bladder cancer TIPE2 cystectomy urothelial carcinoma
ISSN号	1219-4956
DOI	10.3389/pore.2022.1610282
通讯作者	Wang, Yi(wangyi2035@ahmu.edu.cn)
英文摘要	Objective: We sought to identify tumor necrosis factor (TNF)-alpha-induced protein 8-like 2 (TIPE2/TNFAIP8L2) expression in bladder cancer and its relationship to clinicopathological findings and prognosis.Methods: Immunohistochemical (IHC) staining for TIPE2 was performed on 110 archived radical cystectomy specimens. Ten high-power fields were randomly selected from each specimen to observe and record the percentage of immunoreactive cells of TIPE2 in tumor cells (grade 0-4) and the corresponding immunostaining intensity (grade 0-3). The expression score of TIPE2 was obtained by multiplying the results of the above two scores, which ranged from 0 to 12 points. The cut-off point of the sum of the scores were defined as follows: 0-3 scores were defined as negative expression (-); >3 scores were classified as positive expression, < 7, low expression, >= 7, high expression.Results: In 110 cases, TIPE2 was stained in various degrees in bladder cancer tissues, and expressed in both nucleus and cytoplasm. 4.5% (5/110) showed negative expression, 40.9% (45/110) showed low expression, and 54.5% (60/110) showed high expression. TIPE2 expression was negatively correlated with lymph node metastasis (p = 0.004) and disease progression (p = 0.021). Survival curves were plotted to show that patients with high TIPE2 expression had a progression-free survival curve above those with negative/low TIPE2 expression (p = 0.027). In multivariate Cox proportional hazard regression analysis, TIPE2 was a protective factor for progression-free survival in bladder urothelial carcinoma (p = 0.031), pT stage (p = 0.016) was a risk factor for progression-free survival, and age was a risk factor for overall survival (p = 0.020).Conclusion: TIPE2 may be a new biomarker to predict the disease progression and prognosis of patients with urothelial carcinoma of the bladder.
资助项目	Open Fund Project of Anhui Provincial Key Laboratory of Medical Physics and Technology[LMPT201903] ; Scientific Research Fund Project of Anhui Academy of Translational Medicine[2021zhyx-C66]
WOS关键词	INVASION ; STATISTICS ; CARCINOMA ; MIGRATION ; CATENIN ; CELLS ; EMT
WOS研究方向	Oncology ; Pathology
语种	英语
出版者	FRONTIERS MEDIA SA
WOS记录号	WOS:000779327900001
资助机构	Open Fund Project of Anhui Provincial Key Laboratory of Medical Physics and Technology ; Scientific Research Fund Project of Anhui Academy of Translational Medicine
内容类型	期刊论文
源URL	[http://ir.hfcas.ac.cn:8080/handle/334002/128519]
专题	中国科学院合肥物质科学研究院
通讯作者	Wang, Yi
作者单位	1.Anhui Med Univ, Dept Urol, Affiliated Hosp 2, Hefei, Peoples R China 2.Anhui Med Univ, Dept Pathol, Affiliated Hosp 2, Hefei, Peoples R China 3.Chinese Acad Sci, Inst Hlth & Med Technol, Hefei Inst Phys Sci, Anhui Prov Key Lab Med Phys & Technol, Hefei, Peoples R China 4.Anhui Prov Inst Translat Med, Hefei, Peoples R China
推荐引用方式 GB/T 7714	Jiang, Yu,Zhang, Zhiqiang,Wang, Xian,et al. A Novel Prognostic Factor TIPE2 in Bladder Cancer[J]. PATHOLOGY & ONCOLOGY RESEARCH,2022,28.
APA	Jiang, Yu.,Zhang, Zhiqiang.,Wang, Xian.,Feng, Zhenzhong.,Hong, Bo.,...&Wang, Yi.(2022).A Novel Prognostic Factor TIPE2 in Bladder Cancer.PATHOLOGY & ONCOLOGY RESEARCH,28.
MLA	Jiang, Yu,et al."A Novel Prognostic Factor TIPE2 in Bladder Cancer".PATHOLOGY & ONCOLOGY RESEARCH 28(2022).