A liquid-crystal-based immunosensor for the detection of cardiac troponin I

doi:10.1039/d0an00425a

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	A liquid-crystal-based immunosensor for the detection of cardiac troponin I
	C. L. Xia,D. Zhou,Y. M. Su,G. K. Zhou,L. S. Yao,W. M. Sun and Y. J. Liu
刊名	Analyst
	2020
卷号	145 期号:13 页码:4569-4575
ISSN号	0003-2654
DOI	10.1039/d0an00425a
英文摘要	Cardiac troponin I (cTnI) is one of the most sensitive and specific markers of myocardial cell injury, which can detect even minor myocardial damages. It is recognized as the main biochemical marker of the rapid diagnosis of acute myocardial infarction (AMI) and acute coronary syndrome (ACS). In this study, a label-free biosensor that utilizes the birefringence property of a nematic liquid crystal (LC) for the detection of cTnI is demonstrated. A chemically sensitive film with specific molecular recognition ability was decorated on the surface of a substrate, and the LC molecules were arranged in a vertically oriented order under the influence of the sensitive film, and a dark background signal was obtained using a polarizing optical microscope. When the antigen-antibody specifically binds to form a stronger acting force, the orientation of the LC molecules changes, resulting in a bright optical appearance. This LC-based immunosensor not only has the advantages of a facile structure, low cost and excellent specificity but also high sensitivity (a low detection limit of 1 pg ml(-1)), and has a promising future in biomedical related fields.
URL标识	查看原文
语种	英语
内容类型	期刊论文
源URL	[http://ir.ciomp.ac.cn/handle/181722/64654]
专题	中国科学院长春光学精密机械与物理研究所
推荐引用方式 GB/T 7714	C. L. Xia,D. Zhou,Y. M. Su,G. K. Zhou,L. S. Yao,W. M. Sun and Y. J. Liu. A liquid-crystal-based immunosensor for the detection of cardiac troponin I[J]. Analyst,2020,145(13):4569-4575.
APA	C. L. Xia,D. Zhou,Y. M. Su,G. K. Zhou,L. S. Yao,W. M. Sun and Y. J. Liu.(2020).A liquid-crystal-based immunosensor for the detection of cardiac troponin I.Analyst,145(13),4569-4575.
MLA	C. L. Xia,D. Zhou,Y. M. Su,G. K. Zhou,L. S. Yao,W. M. Sun and Y. J. Liu."A liquid-crystal-based immunosensor for the detection of cardiac troponin I".Analyst 145.13(2020):4569-4575.