Construction of a simple and intelligent DNA-based computing system for multiplexing logic operations

doi:10.1016/j.actbio.2020.09.054

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	Construction of a simple and intelligent DNA-based computing system for multiplexing logic operations
	H. M. Geng,Z. Yin,C. Y. Zhou and C. L. Guo
刊名	Acta Biomaterialia
	2020
卷号	118 页码:44-53
ISSN号	1742-7061
DOI	10.1016/j.actbio.2020.09.054
英文摘要	Over the past few decades, DNA-based computing technology has become a rapidly developing technology and shown remarkable capabilities in handling complex computational problems. However, most of the logical operations that DNA computer can achieve are still very basic or using large-scale operations to realize complex functions, especially in mathematics. Graphene oxide (GO) is an ideal nanomaterial for biological computing, which has been used in our previous work to perform basic logic operations. Here, we utilize GO to implement far more complex and large-scale logical computing. For the first time, in this work, we utilize the unique interaction between GO and a variety of classified single-stranded DNAs as the reaction platform, by segmenting and encoding the DNA sequences, and programming the interactions between inputs and between the inputs and reaction platform, two relative large-scale logic operations, 6-bit square-root and 9-bit cube-root logical circuits are realized. This study provides a simple but efficient method for advanced and large-scale logical mathematic operations in biotechnology, opening a new horizon for building biocomputer-based innovative functional devices. (c) 2020 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.
URL标识	查看原文
语种	英语
内容类型	期刊论文
源URL	[http://ir.ciomp.ac.cn/handle/181722/64381]
专题	中国科学院长春光学精密机械与物理研究所
推荐引用方式 GB/T 7714	H. M. Geng,Z. Yin,C. Y. Zhou and C. L. Guo. Construction of a simple and intelligent DNA-based computing system for multiplexing logic operations[J]. Acta Biomaterialia,2020,118:44-53.
APA	H. M. Geng,Z. Yin,C. Y. Zhou and C. L. Guo.(2020).Construction of a simple and intelligent DNA-based computing system for multiplexing logic operations.Acta Biomaterialia,118,44-53.
MLA	H. M. Geng,Z. Yin,C. Y. Zhou and C. L. Guo."Construction of a simple and intelligent DNA-based computing system for multiplexing logic operations".Acta Biomaterialia 118(2020):44-53.