Self-Powered Intracellular Drug Delivery by a Biomechanical Energy-Driven Triboelectric Nanogenerator

doi:10.1002/adma.201807795

CORC > 长春光学精密机械与物理研究所 > 中国科学院长春光学精密机械与物理研究所

	Self-Powered Intracellular Drug Delivery by a Biomechanical Energy-Driven Triboelectric Nanogenerator
	Z.R.Liu; J.H.Nie; B.Miao; J.D.Li; Y.B.Cui; S.Wang
刊名	Advanced Materials
	2019
卷号	31 期号:12 页码:8
关键词	intracellular delivery,nanoneedle,self-powered,transdermal delivery,triboelectric nanogenerator,electroporation,membrane,cells,molecules,platform,therapy,system,Chemistry,Science & Technology - Other Topics,Materials Science,Physics
ISSN号	0935-9648
DOI	10.1002/adma.201807795
英文摘要	Nondestructive, high-efficiency, and on-demand intracellular drug/biomacromolecule delivery for therapeutic purposes remains a great challenge. Herein, a biomechanical-energy-powered triboelectric nanogenerator (TENG)-driven electroporation system is developed for intracellular drug delivery with high efficiency and minimal cell damage in vitro and in vivo. In the integrated system, a self-powered TENG as a stable voltage pulse source triggers the increase of plasma membrane potential and membrane permeability. Cooperatively, the silicon nanoneedle-array electrode minimizes cellular damage during electroporation via enhancing the localized electrical field at the nanoneedle-cell interface and also decreases plasma membrane fluidity for the enhancement of molecular influx. The integrated system achieves efficient delivery of exogenous materials (small molecules, macromolecules, and siRNA) into different types of cells, including hard-to-transfect primary cells, with delivery efficiency up to 90% and cell viability over 94%. Through simple finger friction or hand slapping of the wearable TENGs, it successfully realizes a transdermal biomolecule delivery with an over threefold depth enhancement in mice. This integrated and self-powered system for active electroporation drug delivery shows great prospect for self-tuning drug delivery and wearable medicine.
语种	英语
内容类型	期刊论文
源URL	[http://ir.ciomp.ac.cn/handle/181722/63163]
专题	中国科学院长春光学精密机械与物理研究所
推荐引用方式 GB/T 7714	Z.R.Liu,J.H.Nie,B.Miao,et al. Self-Powered Intracellular Drug Delivery by a Biomechanical Energy-Driven Triboelectric Nanogenerator[J]. Advanced Materials,2019,31(12):8.
APA	Z.R.Liu,J.H.Nie,B.Miao,J.D.Li,Y.B.Cui,&S.Wang.(2019).Self-Powered Intracellular Drug Delivery by a Biomechanical Energy-Driven Triboelectric Nanogenerator.Advanced Materials,31(12),8.
MLA	Z.R.Liu,et al."Self-Powered Intracellular Drug Delivery by a Biomechanical Energy-Driven Triboelectric Nanogenerator".Advanced Materials 31.12(2019):8.