Measurement method of Akkermansia muciniphila by graphene-based transistor for diseases diagnosis | |
Li GX(李恭新)1; Lu, Zhilong1; Luan XL(栾小丽)1; Wang, Zhiguo1; Liu F(刘飞)1; Liu LQ(刘连庆)2,3 | |
刊名 | IEEE Transactions on Nanotechnology |
2021 | |
卷号 | 20页码:332-337 |
关键词 | Akkermansia muciniphila graphene-based transistor diseases diagnosis method |
ISSN号 | 1536-125X |
产权排序 | 2 |
英文摘要 | Akkermansia muciniphila, as a mucin-degrading bacterium of the phylum Verrucomicrobia, associates with several disease states for its concentration in the human intestinal tract. To accuracy and rapidly measure the concentration of A. muciniphila would be a promising candidate for rapid diagnosis of these diseases. Herein, we present a new method to label-free acquire the concentration of A. muciniphila by designing a graphene-based transistor. Relative permittivities of the transistor were varied by adding A. muciniphila with different concentrations. Various conductance changes, which were recorded by the graphene-based transistor, were generated, and, in turn, characterized the concentrations of A. muciniphila. The experimental results indicated that the approach can significantly distinguish different concentrations of A. muciniphila and has certain fault tolerance when the samples containing a small amount of other intestinal bacteria and impurities. The work offers a general measurement method of the concentration of A. muciniphila, and provide a novel and promising method for the diagnosis of several diseases associating with A. muciniphila. |
资助项目 | National Natural Science Foundation of China[61903157] ; National Natural Science Foundation of China[61833007] ; Natural Science Foundation of Jiangsu Province of China[BK20180592] |
WOS研究方向 | Engineering ; Science & Technology - Other Topics ; Materials Science ; Physics |
语种 | 英语 |
WOS记录号 | WOS:000645045200001 |
资助机构 | National Natural Science Foundation of China under Grants 61903157 and 61833007 ; Natural Science Foundation of Jiangsu Province of China under Grant BK20180592 |
内容类型 | 期刊论文 |
源URL | [http://ir.sia.cn/handle/173321/28769] |
专题 | 沈阳自动化研究所_机器人学研究室 |
通讯作者 | Liu LQ(刘连庆) |
作者单位 | 1.Key Laboratory of Advanced Process Control for Light Industry of the Ministry of Education, Jiangnan University, 66374 Wuxi, Jiangsu, China, 214122 2.Shenyang Institute of Automation, Chinese Academy of Sciences, Shenyang, Liaoning, China, 110016 3.Institute for Robotics and Intelligent Manufacturing, Chinese Academy of Sciences, Shenyang 110016, China |
推荐引用方式 GB/T 7714 | Li GX,Lu, Zhilong,Luan XL,et al. Measurement method of Akkermansia muciniphila by graphene-based transistor for diseases diagnosis[J]. IEEE Transactions on Nanotechnology,2021,20:332-337. |
APA | Li GX,Lu, Zhilong,Luan XL,Wang, Zhiguo,Liu F,&Liu LQ.(2021).Measurement method of Akkermansia muciniphila by graphene-based transistor for diseases diagnosis.IEEE Transactions on Nanotechnology,20,332-337. |
MLA | Li GX,et al."Measurement method of Akkermansia muciniphila by graphene-based transistor for diseases diagnosis".IEEE Transactions on Nanotechnology 20(2021):332-337. |
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