Charged Particle Irradiation for Pancreatic Cancer: A Systematic Review of In Vitro Studies

doi:10.3389/fonc.2021.775597

	Charged Particle Irradiation for Pancreatic Cancer: A Systematic Review of In Vitro Studies
	Wang, Dandan 1,2; Liu, Ruifeng 1,3,4; Zhang, Qiuning 1,3,4; Luo, Hongtao 1,3,4; Chen, Junru 1,2; Dong, Meng 1,2; Wang, Yuhang 1,2; Ou, Yuhong 1,2; Liu, Zhiqiang 1,3,4; Sun, Shilong 1,3,4
刊名	FRONTIERS IN ONCOLOGY
	2022-01-04
卷号	11 页码:13
关键词	pancreatic cancer particle radiation clonogenic survival DDR migration invasion systematic review
ISSN号	2234-943X
DOI	10.3389/fonc.2021.775597
通讯作者	Zhang, Qiuning(zhangqn@impcas.ac.cn) ; Wang, Xiaohu(xhwang@impcas.ac.cn)
英文摘要	Purpose: Given the higher precision accompanied by optimized sparing of normal tissue, charged particle therapy was thought of as a promising treatment for pancreatic cancer. However, systematic preclinical studies were scarce. We aimed to investigate the radiobiological effects of charged particle irradiation on pancreatic cancer cell lines.Methods: A systematic literature search was performed in EMBASE (OVID), Medline (OVID), and Web of Science databases. Included studies were in vitro English publications that reported the radiobiological effects of charged particle irradiation on pancreatic cancer cells.Results: Thirteen carbon ion irradiation and seven proton irradiation in vitro studies were included finally. Relative biological effectiveness (RBE) values of carbon ion irradiation and proton irradiation in different human pancreatic cancer cell lines ranged from 1.29 to 4.5, and 0.6 to 2.1, respectively. The mean of the surviving fraction of 2 Gy (SF2) of carbon ion, proton, and photon irradiation was 0.18 & PLUSMN; 0.11, 0.48 & PLUSMN; 0.11, and 0.57 & PLUSMN; 0.13, respectively. Carbon ion irradiation induced more G2/M arrest and a longer-lasting expression of gamma H2AX than photon irradiation. Combination therapies enhanced the therapeutic effects of pancreatic cell lines with a mean standard enhancement ratio (SER) of 1.66 & PLUSMN; 0.63 for carbon ion irradiation, 1.55 & PLUSMN; 0.27 for proton irradiation, and 1.52 & PLUSMN; 0.30 for photon irradiation. Carbon ion irradiation was more effective in suppressing the migration and invasion than photon irradiation, except for the PANC-1 cells.Conclusions: Current in vitro evidence demonstrates that, compared with photon irradiation, carbon ion irradiation offers superior radiobiological effects in the treatment of pancreatic cancer. Mechanistically, high-LET irradiation may induce complex DNA damage and ultimately promote genomic instability and cell death. Both carbon ion irradiation and proton irradiation confer similar sensitization effects in comparison with photon irradiation when combined with chemotherapy or targeted therapy.
资助项目	Science and Technology Plan Project of Chengguan District of Lanzhou[2020-2-2-5] ; Talent innovation and venture project of Lanzhou city[2017-RC-23] ; Talent innovation and venture project of Lanzhou city[2020-RC-113] ; Key R&D Program of Science and Technology Department of Gansu Province[20YF8FA116] ; Lanzhou KejinTaiji Corporation, Ltd.[BMP-B-02-002]
WOS关键词	LINEAR-ENERGY-TRANSFER ; CARBON-ION RADIATION ; INTENSITY-MODULATED PHOTON ; DNA-DAMAGE ; BIOLOGICAL EFFECTIVENESS ; CELL-LINES ; PROTON ; THERAPY ; GEMCITABINE ; BEAMS
WOS研究方向	Oncology
语种	英语
出版者	FRONTIERS MEDIA SA
WOS记录号	WOS:000747696100001
资助机构	Science and Technology Plan Project of Chengguan District of Lanzhou ; Talent innovation and venture project of Lanzhou city ; Key R&D Program of Science and Technology Department of Gansu Province ; Lanzhou KejinTaiji Corporation, Ltd.
内容类型	期刊论文
源URL	[http://119.78.100.186/handle/113462/142284]
专题	中国科学院近代物理研究所
通讯作者	Zhang, Qiuning; Wang, Xiaohu
作者单位	1.Chinese Acad Sci, Inst Modern Phys, Lanzhou, Peoples R China 2.Lanzhou Univ, Sch Clin Med 1, Lanzhou, Peoples R China 3.Univ Chinese Acad Sci, Dept Postgrad, Beijing, Peoples R China 4.Lanzhou Heavy Hosp, Heavy Therapy Ctr, Lanzhou, Peoples R China 5.Lanzhou Univ, Sch Basic Med Sci, Evidence Based Med Ctr, Lanzhou, Peoples R China
推荐引用方式 GB/T 7714	Wang, Dandan,Liu, Ruifeng,Zhang, Qiuning,et al. Charged Particle Irradiation for Pancreatic Cancer: A Systematic Review of In Vitro Studies[J]. FRONTIERS IN ONCOLOGY,2022,11:13.
APA	Wang, Dandan.,Liu, Ruifeng.,Zhang, Qiuning.,Luo, Hongtao.,Chen, Junru.,...&Wang, Xiaohu.(2022).Charged Particle Irradiation for Pancreatic Cancer: A Systematic Review of In Vitro Studies.FRONTIERS IN ONCOLOGY,11,13.
MLA	Wang, Dandan,et al."Charged Particle Irradiation for Pancreatic Cancer: A Systematic Review of In Vitro Studies".FRONTIERS IN ONCOLOGY 11(2022):13.