The potential of ionic liquids in biopharmaceutical engineering

doi:10.1016/j.cjche.2020.11.015

	The potential of ionic liquids in biopharmaceutical engineering
	Lin, Xuan; Su, Zhiguo; Yang, Yanli; Zhang, Songping
刊名	CHINESE JOURNAL OF CHEMICAL ENGINEERING
	2021-02-01
卷号	30 页码:236-243
关键词	Ionic liquids Biopharmaceutical engineering Biomacromolecules Stabilization Vaccine Delivery
ISSN号	1004-9541
DOI	10.1016/j.cjche.2020.11.015
英文摘要	Biopharmaceuticals, such as proteins, peptides, nucleic acids and vaccines, bring about great hopes for the prevention and treatment of various diseases, but the industrialization of these products still faces challenges such as structural instability, inefficient bioactivity and low bioavailability. Ionic liquids (ILs), the marvelous solvent media with inimitable and tunable properties, may provide alternative solutions to overcome the above problems of biopharmaceutical industry. Progress has gradually been made through studies by combination of ILs with biomacromolecules. The applications involved the stabilization, protection, and delivery of biopharmaceuticals. Recent trends are being forwarded to using ILs in vaccines and nucleic acid drugs. However, challenges remain on the toxicity and safety issues. Besides, the cost of adding ILs to the benefits of biopharmaceuticals need to be considered. (C) 2020 The Chemical Industry and Engineering Society of China, and Chemical Industry Press Co., Ltd. All rights reserved.
资助项目	National Natural Science Foundation of China[21808226] ; National Natural Science Foundation of China[31970872] ; National Natural Science Foundation of China[21821005]
WOS关键词	CONFORMATIONAL STABILITY ; CHEMICAL-STABILITY ; PROTEIN STABILITY ; ACUTE TOXICITY ; DELIVERY ; VACCINE ; DRUG ; INSULIN ; STABILIZATION ; DNA
WOS研究方向	Engineering
语种	英语
出版者	CHEMICAL INDUSTRY PRESS CO LTD
WOS记录号	WOS:000651052100024
资助机构	National Natural Science Foundation of China
内容类型	期刊论文
源URL	[http://ir.ipe.ac.cn/handle/122111/48985]
专题	中国科学院过程工程研究所
通讯作者	Yang, Yanli; Zhang, Songping
作者单位	Chinese Acad Sci, Inst Proc Engn, State Key Lab Biochem Engn, Beijing 100190, Peoples R China
推荐引用方式 GB/T 7714	Lin, Xuan,Su, Zhiguo,Yang, Yanli,et al. The potential of ionic liquids in biopharmaceutical engineering[J]. CHINESE JOURNAL OF CHEMICAL ENGINEERING,2021,30:236-243.
APA	Lin, Xuan,Su, Zhiguo,Yang, Yanli,&Zhang, Songping.(2021).The potential of ionic liquids in biopharmaceutical engineering.CHINESE JOURNAL OF CHEMICAL ENGINEERING,30,236-243.
MLA	Lin, Xuan,et al."The potential of ionic liquids in biopharmaceutical engineering".CHINESE JOURNAL OF CHEMICAL ENGINEERING 30(2021):236-243.