A perspective review on mixing effect for modeling and simulation of reactive and antisolvent crystallization processes | |
Qu, Yanli1,2; Cheng, Jingcai1,3; Mao, Zai-Sha1; Yang, Chao1,2,3 | |
刊名 | REACTION CHEMISTRY & ENGINEERING |
2021-02-01 | |
卷号 | 6期号:2页码:183-196 |
ISSN号 | 2058-9883 |
DOI | 10.1039/d0re00223b |
英文摘要 | Reactive and antisolvent crystallization processes are efficient techniques for the production of fine chemicals and pharmaceuticals. These processes are usually characterized by high levels of supersaturation and fast primary crystallization kinetics. Understanding the mixing mechanism and its interaction with various crystallization phenomena is advantageous for achieving robust control of these crystallization processes and the desired crystal properties. Much modeling effort has been devoted to accounting for the combined effects of mixing on various scales and the complicated kinetic phenomena involved in these processes as complementary to experimental investigations. This article provides a review on the numerical simulation of reactive and antisolvent crystallization processes with an emphasis on modeling the mixing effect. Relevant Lagrangian mechanistic micromixing models and probability density function (PDF) approaches are introduced followed by simulation examples from the literature. Various examples are categorized into four groups according to the different coupling between mixing, crystallization kinetics and flow field. Also, some suggestions on further model development are given to enhance their predictive performances and broaden the range of application. |
资助项目 | National Natural Science Foundation of China[21938009] ; National Natural Science Foundation of China[21776284] ; National Natural Science Foundation of China[91934301] ; National Key Research and Development Program[2019YFC1904204] ; External Cooperation Program of BIC, Chinese Academy of Sciences[122111KYSB20190032] ; Key Research Program of Frontier Sciences, CAS[QYZDJ-SSW-JSC030] |
WOS研究方向 | Chemistry ; Engineering |
语种 | 英语 |
出版者 | ROYAL SOC CHEMISTRY |
WOS记录号 | WOS:000616272700001 |
资助机构 | National Natural Science Foundation of China ; National Key Research and Development Program ; External Cooperation Program of BIC, Chinese Academy of Sciences ; Key Research Program of Frontier Sciences, CAS |
内容类型 | 期刊论文 |
源URL | [http://ir.ipe.ac.cn/handle/122111/43647] |
专题 | 中国科学院过程工程研究所 |
通讯作者 | Cheng, Jingcai; Yang, Chao |
作者单位 | 1.Chinese Acad Sci, Inst Proc Engn, CAS Key Lab Green Proc & Engn, Beijing 100190, Peoples R China 2.Univ Chinese Acad Sci, Sch Chem Engn, Beijing 100049, Peoples R China 3.Chinese Acad Sci, Innovat Acad Green Manufacture, Beijing 100190, Peoples R China |
推荐引用方式 GB/T 7714 | Qu, Yanli,Cheng, Jingcai,Mao, Zai-Sha,et al. A perspective review on mixing effect for modeling and simulation of reactive and antisolvent crystallization processes[J]. REACTION CHEMISTRY & ENGINEERING,2021,6(2):183-196. |
APA | Qu, Yanli,Cheng, Jingcai,Mao, Zai-Sha,&Yang, Chao.(2021).A perspective review on mixing effect for modeling and simulation of reactive and antisolvent crystallization processes.REACTION CHEMISTRY & ENGINEERING,6(2),183-196. |
MLA | Qu, Yanli,et al."A perspective review on mixing effect for modeling and simulation of reactive and antisolvent crystallization processes".REACTION CHEMISTRY & ENGINEERING 6.2(2021):183-196. |
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