Injectable ferrimagnetic silk fibroin hydrogel for magnetic hyperthermia ablation of deep tumor | |
Qian, Kun-Yu2; Song, Yonghong2; Yan, Xu2; Dong, Liang3; Xue, Jingzhe2; Xu, Yunjun4; Wang, Bao1; Cao, Baoqiang5; Hou, Qingbing5; Peng, Wei5 | |
刊名 | BIOMATERIALS |
2020-11-01 | |
卷号 | 259页码:11 |
关键词 | Silk fibroin Hydrogel Ferrimagnetic Hyperthermia Deep tumor |
ISSN号 | 0142-9612 |
DOI | 10.1016/j.biomaterials.2020.120299 |
英文摘要 | Due to the well-recognized biocompatibility, silk fibroin hydrogels have been developed for biomedical appli-cations including bone regeneration, drug delivery and cancer therapy. For the treatment of cancer, silk-based photothermal agents exhibit the high photothermal conversion efficiency, but the limited light penetration depth of photothermal therapy restricts the treatment of some tumors in deep positions, such as liver tumor and glioma. To provide an alternative strategy, here we developed an injectable magnetic hydrogel based on silk fibroin and iron oxide nanocubes (IONCs). The as-prepared ferrimagnetic silk fibroin hydrogel could be easily injected through a syringe into tumor, especially rabbit hepatocellular carcinoma in deeper positions using ultrasound-guided interventional treatment. Compared with photothermal agents, the embedded IONCs endowed the ferrimagnetic silk fibroin hydrogel with remote hyperthermia performance under an alternating magnetic field, resulting in the effective magnetic hyperthermia of deep tumors including subcutaneously implanted tumor model in Balb/c mouse after the coverage of a fresh pork tissue and orthotopic transplantation liver tumor in rabbit. Furthermore, due to the confinement of IONCs in silk fibroin hydrogel, the undesired thermal damage toward normal tissue could be avoided compared with directly administrating monodispersed magnetic nanoparticles. |
资助项目 | National Natural Science Foundation of China[51972090] ; National Natural Science Foundation of China[51572067] ; National Natural Science Foundation of China[21501039] ; National Natural Science Foundation of China[21701165] ; National Natural Science Foundation of China[51673074] ; Fundamental Research Funds for the Central Universities[JZ2018HGPA0269] ; Natural Science Foundation of Anhui Province[2008085J06] ; Foundation for State Key Laboratory of Biochemical Engineering[Y624012124] ; China Postdoctoral Science Foundation[2017M612079] |
WOS关键词 | IRON-OXIDE NANOCUBES ; IN-VITRO ; NANOPARTICLES ; THERMOTHERAPY ; DELIVERY ; THERAPY ; DESIGN ; MRI |
WOS研究方向 | Engineering ; Materials Science |
语种 | 英语 |
出版者 | ELSEVIER SCI LTD |
WOS记录号 | WOS:000571532400002 |
资助机构 | National Natural Science Foundation of China ; Fundamental Research Funds for the Central Universities ; Natural Science Foundation of Anhui Province ; Foundation for State Key Laboratory of Biochemical Engineering ; China Postdoctoral Science Foundation |
内容类型 | 期刊论文 |
源URL | [http://ir.ipe.ac.cn/handle/122111/42205] |
专题 | 中国科学院过程工程研究所 |
通讯作者 | Xue, Jingzhe; Cao, Baoqiang; Lu, Yang |
作者单位 | 1.Chinese Acad Sci, State Key Lab Biochem Engn, Inst Proc Engn, Beijing 100190, Peoples R China 2.Hefei Univ Technol, Key Lab Metab & Regulat Major Dis Anhui Higher Ed, Intelligent Interconnected Syst Lab Anhui Prov, Key Lab Adv Catalyt Mat & React Engn,Sch Chem & C, Hefei 230009, Anhui, Peoples R China 3.Univ Sci & Technol China, Hefei Natl Lab Phys Sci Microscale, Hefei 230026, Peoples R China 4.Univ Sci & Technol China, Affiliated Hosp USTC 1, Dept Radiol, Div Life Sci & Med, Hefei 230036, Anhui, Peoples R China 5.Anhui 2 Prov Peoples Hosp, Dept Intervent Radiol, Dept Ultrason, Dept Gen Surg, Hefei 230041, Anhui, Peoples R China |
推荐引用方式 GB/T 7714 | Qian, Kun-Yu,Song, Yonghong,Yan, Xu,et al. Injectable ferrimagnetic silk fibroin hydrogel for magnetic hyperthermia ablation of deep tumor[J]. BIOMATERIALS,2020,259:11. |
APA | Qian, Kun-Yu.,Song, Yonghong.,Yan, Xu.,Dong, Liang.,Xue, Jingzhe.,...&Lu, Yang.(2020).Injectable ferrimagnetic silk fibroin hydrogel for magnetic hyperthermia ablation of deep tumor.BIOMATERIALS,259,11. |
MLA | Qian, Kun-Yu,et al."Injectable ferrimagnetic silk fibroin hydrogel for magnetic hyperthermia ablation of deep tumor".BIOMATERIALS 259(2020):11. |
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