Particulate Alum via Pickering Emulsion for an Enhanced COVID-19 Vaccine Adjuvant

doi:10.1002/adma.202004210

	Particulate Alum via Pickering Emulsion for an Enhanced COVID-19 Vaccine Adjuvant
	Peng, Sha 1,2; Cao, Fengqiang 1,3; Xia, Yufei 1,4,5; Gao, Xiao-Dong 2; Dai, Lianpan 6; Yan, Jinghua 7; Ma, Guanghui 1,4,5
刊名	ADVANCED MATERIALS
	2020-08-30
页码	7
关键词	alum cellular immune responses COVID-19 vaccine adjuvant Pickering emulsion SARS-CoV-2
ISSN号	0935-9648
DOI	10.1002/adma.202004210
英文摘要	For rapid response against the prevailing COVID-19 (coronavirus disease 19), it is a global imperative to exploit the immunogenicity of existing formulations for safe and efficient vaccines. As the most accessible adjuvant, aluminum hydroxide (alum) is still the sole employed adjuvant in most countries. However, alum tends to attach on the membrane rather than entering the dendritic cells (DCs), leading to the absence of intracellular transfer and process of the antigens, and thus limits T-cell-mediated immunity. To address this, alum is packed on the squalene/water interphase is packed, forming an alum-stabilized Pickering emulsion (PAPE). "Inheriting" from alum and squalene, PAPE demonstrates a good biosafety profile. Intriguingly, with the dense array of alum on the oil/water interphase, PAPE not only adsorbs large quantities of SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) antigens, but also harbors a higher affinity for DC uptake, which provokes the uptake and cross-presentation of the delivered antigens. Compared with alum-treated groups, more than six times higher antigen-specific antibody titer and three-fold more IFN-gamma-secreting T cells are induced, indicating the potent humoral and cellular immune activations. Collectively, the data suggest that PAPE may provide potential insights toward a safe and efficient adjuvant platform for the enhanced COVID-19 vaccinations.
资助项目	Foundation for Innovative Research Groups of the National Natural Science Foundation of China[21821005] ; Pilot Project of Chinese Academy of Sciences[XDB29040303] ; Original Innovation Project of Basic Frontier Scientific Research Program of Chinese Academy of Sciences[2020000071] ; Youth Project of National Natural Science Foundation of China[21908229] ; National Natural Science Foundation of China[21776287] ; Youth Innovation Promotion Association of the Chinese Academy of Sciences[2020000053] ; Key External Cooperation Program of Chinese Academy of Sciences[122111KYSB20180021]
WOS关键词	T-CELLS ; CLEARANCE ; MICROGELS ; DESIGN ; VIRUS ; MERS
WOS研究方向	Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
语种	英语
出版者	WILEY-V C H VERLAG GMBH
WOS记录号	WOS:000564582700001
资助机构	Foundation for Innovative Research Groups of the National Natural Science Foundation of China ; Pilot Project of Chinese Academy of Sciences ; Original Innovation Project of Basic Frontier Scientific Research Program of Chinese Academy of Sciences ; Youth Project of National Natural Science Foundation of China ; National Natural Science Foundation of China ; Youth Innovation Promotion Association of the Chinese Academy of Sciences ; Key External Cooperation Program of Chinese Academy of Sciences
内容类型	期刊论文
源URL	[http://ir.ipe.ac.cn/handle/122111/41969]
专题	中国科学院过程工程研究所
通讯作者	Xia, Yufei; Ma, Guanghui
作者单位	1.Chinese Acad Sci, Inst Proc Engn, State Key Lab Biochem Engn, Beijing 100190, Peoples R China 2.Jiangnan Univ, Sch Biotechnol, Minist Educ, Key Lab Carbohydrate Chem & Biotechnol, Wuxi 214122, Jiangsu, Peoples R China 3.Tokyo Univ Agr & Technol, Grad Sch Bioapplicat & Syst Engn, 2-24-16 Nakacho, Koganei, Tokyo 1848588, Japan 4.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 5.Chinese Acad Sci, Innovat Acad Green Manufacture, Beijing 100190, Peoples R China 6.Chinese Acad Sci, Beijing Inst Life Sci, Beijing 100101, Peoples R China 7.Chinese Acad Sci, Inst Microbiol, Beijing 100101, Peoples R China
推荐引用方式 GB/T 7714	Peng, Sha,Cao, Fengqiang,Xia, Yufei,et al. Particulate Alum via Pickering Emulsion for an Enhanced COVID-19 Vaccine Adjuvant[J]. ADVANCED MATERIALS,2020:7.
APA	Peng, Sha.,Cao, Fengqiang.,Xia, Yufei.,Gao, Xiao-Dong.,Dai, Lianpan.,...&Ma, Guanghui.(2020).Particulate Alum via Pickering Emulsion for an Enhanced COVID-19 Vaccine Adjuvant.ADVANCED MATERIALS,7.
MLA	Peng, Sha,et al."Particulate Alum via Pickering Emulsion for an Enhanced COVID-19 Vaccine Adjuvant".ADVANCED MATERIALS (2020):7.