Tumor microenvironment-oriented adaptive nanodrugs based on peptide self-assembly

doi:10.1039/d0sc02937h

	Tumor microenvironment-oriented adaptive nanodrugs based on peptide self-assembly
	Li, Shukun 1,3; Zhang, Wenjia 2; Xue, Huadan 2; Xing, Ruirui 1; Yan, Xuehai 1,3
刊名	CHEMICAL SCIENCE
	2020-09-07
卷号	11 期号:33 页码:8644-8656
ISSN号	2041-6520
DOI	10.1039/d0sc02937h
英文摘要	The aberrant metabolism of tumor cells creates an inimitable microenvironment featuring acidic pH, high glutathione (GSH) levels, and overexpression of certain enzymes, which benefits the overwhelming progress of a tumor. Peptide self-assembly, emerging as a biofriendly and versatile fabrication strategy, harnesses multiple noncovalent interactions to obtain a variety of nanostructures tailored on demand. Orchestrating the reversible nature of noncovalent interactions and abnormal physiological parameters in the tumor microenvironment enables peptide-based nanodrugs to be targetable or switchable, thereby improving the drugs' bioavailability and optimizing the treatment outcome. This review will focus on peptide-modulated self-assembly of photosensitizers, chemotherapeutic drugs, immunoactive agents for tumor microenvironment-oriented adaptive phototherapy, chemotherapy, immunotherapy and combinatorial therapy. We will emphasize the building block design, the intermolecular interaction principle, adaptive structural transformation in the tumor microenvironment and corresponding therapeutic efficacy, and aim to elucidate the critical role of peptide-modulated, tumor microenvironment-oriented adaptive assemblies in improving the therapeutic index. Challenges and opportunities will be covered as well to advance the development and clinical application of tumor therapies based on peptide self-assembly materials and techniques.
资助项目	National Natural Science Foundation of China[21802144] ; National Natural Science Fund BRICS STI Framework Program[51861145304] ; Innovation Research Community Science Fund[21821005] ; Key Research Program of Frontier Sciences of Chinese Academy of Sciences (CAS)[QYZDB-SSW-JSC034]
WOS关键词	PHOTODYNAMIC THERAPY ; SUPRAMOLECULAR HYDROGELS ; EMERGING APPLICATIONS ; BETA-SHEET ; PH ; DELIVERY ; NANOPARTICLES ; CONJUGATE ; VACCINE ; NANOMATERIALS
WOS研究方向	Chemistry
语种	英语
出版者	ROYAL SOC CHEMISTRY
WOS记录号	WOS:000562597500001
资助机构	National Natural Science Foundation of China ; National Natural Science Fund BRICS STI Framework Program ; Innovation Research Community Science Fund ; Key Research Program of Frontier Sciences of Chinese Academy of Sciences (CAS)
内容类型	期刊论文
源URL	[http://ir.ipe.ac.cn/handle/122111/41841]
专题	中国科学院过程工程研究所
通讯作者	Xue, Huadan; Xing, Ruirui; Yan, Xuehai
作者单位	1.Chinese Acad Sci, Inst Proc Engn, State Key Lab Biochem Engn, Beijing 100190, Peoples R China 2.Peking Union Med Coll Hosp, Dept Radiol, Beijing 100730, Peoples R China 3.Univ Chinese Acad Sci, Sch Chem Engn, Beijing 100049, Peoples R China
推荐引用方式 GB/T 7714	Li, Shukun,Zhang, Wenjia,Xue, Huadan,et al. Tumor microenvironment-oriented adaptive nanodrugs based on peptide self-assembly[J]. CHEMICAL SCIENCE,2020,11(33):8644-8656.
APA	Li, Shukun,Zhang, Wenjia,Xue, Huadan,Xing, Ruirui,&Yan, Xuehai.(2020).Tumor microenvironment-oriented adaptive nanodrugs based on peptide self-assembly.CHEMICAL SCIENCE,11(33),8644-8656.
MLA	Li, Shukun,et al."Tumor microenvironment-oriented adaptive nanodrugs based on peptide self-assembly".CHEMICAL SCIENCE 11.33(2020):8644-8656.