Coordination self-assembly of natural flavonoids into robust nanoparticles for enhanced in vitro chemo and photothermal cancer therapy

doi:10.1016/j.colsurfa.2020.124805

	Coordination self-assembly of natural flavonoids into robust nanoparticles for enhanced in vitro chemo and photothermal cancer therapy
	Liu, Yilin 1; Zhao, Luyang 2; Shen, Guizhi 2; Chang, Rui 2,3; Zhang, Yi 1; Yan, Xuehai 2,3
刊名	COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
	2020-08-05
卷号	598 页码:7
关键词	Flavonoids Luteolin Coordination self-assembly Nanoparticles Cancer therapy
ISSN号	0927-7757
DOI	10.1016/j.colsurfa.2020.124805
英文摘要	Utilizing small natural molecules from traditional Chinese medicines is highly promising and advantageous in curing diverse diseases. However, the clinical translation of many of these molecular drugs was hindered due to the vulnerable chemical structure and poor solubility. Herein, we reported a coordination-driven assembly strategy to synchronously enhance the stability and solubility of a typical natural molecular drug (luteolin) through the formation of nanoparticles. The resulting nanoparticles showed much enhanced solubility in physiological environment, broadened absorption spectrum to the near-infrared region, and high stability against oxidation. Intriguingly, the coordinated assembly with ferric ion introduces the supramolecular photothermal effects, enabling the nanoparticles to act as either a chemotherapeutic agent or a photothermal agent. This work represents that the coordination assembly strategy is facile and efficient for design of nanodrugs starting from naturally-derived molecular drugs and greatly enhance their therapeutic efficacy.
资助项目	National Natural Science Foundation of China[51861145304] ; National Natural Science Foundation of China[21703252] ; National Natural Science Foundation of China[21802144] ; Innovation Research Community Science Fund[21821005] ; Key Research Program of Frontier Sciences of the Chinese Academy of Sciences (CAS)[QYZDB-SSW-JSC034]
WOS关键词	LUTEOLIN ; DELIVERY ; PRODUCTS ; CELL
WOS研究方向	Chemistry
语种	英语
出版者	ELSEVIER
WOS记录号	WOS:000561642700007
资助机构	National Natural Science Foundation of China ; Innovation Research Community Science Fund ; Key Research Program of Frontier Sciences of the Chinese Academy of Sciences (CAS)
内容类型	期刊论文
源URL	[http://ir.ipe.ac.cn/handle/122111/41736]
专题	中国科学院过程工程研究所
通讯作者	Shen, Guizhi; Zhang, Yi; Yan, Xuehai
作者单位	1.Cent South Univ, Coll Chem & Chem Engn, Hunan Prov Key Lab Micro & Nano Mat Interface Sci, Changsha 410083, Hunan, Peoples R China 2.Chinese Acad Sci, Inst Proc Engn, State Key Lab Biochem Engn, 1 North Second St, Beijing 100190, Peoples R China 3.Univ Chinese Acad Sci, Sch Chem Engn, Beijing 100049, Peoples R China
推荐引用方式 GB/T 7714	Liu, Yilin,Zhao, Luyang,Shen, Guizhi,et al. Coordination self-assembly of natural flavonoids into robust nanoparticles for enhanced in vitro chemo and photothermal cancer therapy[J]. COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS,2020,598:7.
APA	Liu, Yilin,Zhao, Luyang,Shen, Guizhi,Chang, Rui,Zhang, Yi,&Yan, Xuehai.(2020).Coordination self-assembly of natural flavonoids into robust nanoparticles for enhanced in vitro chemo and photothermal cancer therapy.COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS,598,7.
MLA	Liu, Yilin,et al."Coordination self-assembly of natural flavonoids into robust nanoparticles for enhanced in vitro chemo and photothermal cancer therapy".COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS 598(2020):7.