本文对某难处理铜铅锌多金属硫化矿进行选矿全流程试验研究。研究目的是提供该矿石合理的选矿工艺流程及方案，为后续的扩大连选试验和工业试验提供科学依据和数据支撑。由于该铜铅锌多金属矿属复杂难选多金属硫化矿石，铜铅锌矿物之间嵌布关系极其复杂，尤以闪锌矿为最。铜、锌硫化物主要呈微细脉状，或稀疏浸染状分布于石英缝隙中。原矿中云母含量大，可浮性好，严重干扰铜铅锌矿物的浮选，并且对铜铅锌精矿的质量影响很大，这些都大大增加了该铜铅锌多金属矿石的选矿难度。针对以上矿石特性，确定相应药剂制度如下：（1）采用对黄铜矿选择性较好的捕收剂BP，确保了铜的回收率和铜精矿质量。（2）利用高效抑制剂 GJ和DM来抑制云母作用，控制了云母对铜精矿浮选的影响，完成了对矿石中铜矿和云母的有效分离。（3）组合抑制剂硫化钠+硫酸锌+亚硫酸钠对铅锌具有较强的抑制效果，确保了铜精矿中含铅锌低，实现了铜与铅锌的有效分离。提出了创新性的浮选流程：（1）采用优先浮铜—快速浮铅—铅锌混浮的先进流程，获得合格的铜精矿、铅精矿、铅锌精矿。（2）通过优先浮铜技术，进行两段铜粗选作业成功实现铜、云母与铅锌的分离；在优先浮铜阶段，引进铜精扫选作业，将大量的云母快速除去，大大降低了浮选过程中云母对浮选的影响。（3）在铅锌混浮之前创新性的增加快速浮铅作业，不仅可以获得一个质量好的铅精矿而且又不影响后续铅锌精矿的质量，能为企业增加经济效益。通过多次难处理铜铅锌多金属硫化矿的选矿工艺验证试验，最终获得了如下试验指标：铜精矿含铜23.28%、含铅7.13%、含锌4.25%，铜回收率76.22%；铅精矿含铅74.53%、含铜0.71%、含锌5.65%，铅回收率32.03%；铅锌精矿含铅17.59%、含锌33.74%，含铜0.63%，铅回收率47.87%、锌回收率80.20%。 ;The whole beneficiation process of Cu-Pb-Zn poly-metallic sulfide ore is investigated in the present paper. The aim of this study is to obtain the reasonable beneficiation process, and to supply the scientific basis and data support for subsequent successive pilot test and industry test.This Cu-Pb-Zn poly-metallic sulfide ore is refractory ore. They are extremely complicated for the embedded properties of copper, lead and zinc minerals, especially for blende. Copper and zinc sulfides are distributed in quartz gap mainly in the form of fine vein and sparsely disseminated structure. Raw ore has a high mica content. Mica exhibits good floatability, which could severely interfere with the floatation of copper, lead and zinc minerals, and greatly affect the qualities of copper, lead and zinc concentrates. This results in beneficiation difficulty of the Cu-Pb-Zn poly-metallic sulfide ore.According to above ore characters, the following reagent regimes are made. (1) Collector BP, a good selective collector for chalcopyrite, is adopted to ensure the recovery rate of copper and the quality of copper concentrate. (2) The efficient inhibitors DM and GJ are used to restrain mica, which could reduce the impact of mica on the floatation of copper concentrate and achieve effective segregation of copper ore and mica in raw ore. (3) Combined inhibitor of sodium sulphide, zinc sulfate and sodium sulfite has a strong inhibiting effect on lead and zinc, which could ensure the low content of lead and zinc in copper concentrate and realize effective separation of copper and lead/zinc. An innovative floatation process is developed. (1) Advanced process of copper preferential flotation, lead rapid floatation and lead and zinc bulk floatation is applied to obtain qualified copper concentrate, lead concentrate and lead and zinc concentrate. (2) The separation of copper, mica and lead and zinc is achieved thorough two stages of copper rough floatation operation by copper preferential flotation technology. Scavenging is introduced into the stage of copper preferential flotation to rapidly remove large amount of mica and reduce the impact of mica on floatation. (3) Lead rapid floatation is innovatively added before lead and zinc bulk floatation, which not only obtains the qualified lead concentrate, but also does not affect the quality of subsequent lead and zinc concentrate, and increases the economic benefits of enterprise. The following test indexes are obtained through beneficiation process confirmatory experiment of refractory Cu-Pb-Zn poly-metallic sulfide ore. The copper, lead and zinc content of copper concentrate are 23.28%, 7.13%, 4.25%, respectively, and copper recovery rate is 76.22%. They are 0.71%, 74.53% and 5.65% for lead concentrate, respectively, and lead recovery rate is 32.03%. They are 0.63%, 33.74% and 17.59% for lead and zinc concentrate, respectively, and lead and zinc recovery rates are 47.87% and 80.20%, respectively.