Thioether-bridged mesoporous organosilica nanocapsules with weak acid-triggered charge reversal for drug delivery

doi:10.1016/j.micromeso.2020.110242

	Thioether-bridged mesoporous organosilica nanocapsules with weak acid-triggered charge reversal for drug delivery
	Zhou, Mengyun 2; Xing, Yi 2; Li, Weike 2; Li, Xiaoyu 1; Zhang, Xueji 2; Du, Xin 2
刊名	MICROPOROUS AND MESOPOROUS MATERIALS
	2020-08-01
卷号	302 页码:10
关键词	Mesoporous organosilica Thioether-bridged framework Nanocapsules Charge reversal Drug delivery
ISSN号	1387-1811
DOI	10.1016/j.micromeso.2020.110242
英文摘要	The drug delivery nanosystems with weak acid-triggered surface charge reversal function should be promising for efficient chemotherapy due to the prolonged blood circulation and enhanced the cellular uptake. However, there are only limited reports up to now. In this study, we fabricated a hybrid nanocapsule with a negative-to-positive charge-reversal outer layer triggered by the weak acidity in tumor microenvironment. The short branched polyethylenimine (PEI) with positive charge and weak acid-sensitive hexahydmphthalic anhydride with negative charge were successively modified on the surface of small uniform thioether-bridged hollow mesoporous silica nanospheres with multiple cavities. The modification of PEI as a linker was more favorable for charge reversal than that of aminopropyl group. The constructed hybrid nanocapsules exhibited weak acid (pH 6.0)-triggered charge reversal and drug release behaviors, thus effectively inhibiting the growth of A549 cancer cells. The surface functionalization of hybrid nanocapsules opens new opportunities for the development of silica-based hybrid nanosystems for promising drug delivery.
资助项目	Fundamental Research Funds for the Central Universities[FRF-TP-19-017B1] ; National Natural Science Foundation of China[21501009] ; National Natural Science Foundation of China[51671181] ; Beijing Municipal Science and Technology Commission[z131102002813058]
WOS关键词	SILICA NANOPARTICLES ; SILSESQUIOXANE FRAMEWORK ; CONTROLLED-RELEASE ; EFFICIENT ; NANOHYBRIDS
WOS研究方向	Chemistry ; Science & Technology - Other Topics ; Materials Science
语种	英语
出版者	ELSEVIER
WOS记录号	WOS:000532052100046
资助机构	Fundamental Research Funds for the Central Universities ; National Natural Science Foundation of China ; Beijing Municipal Science and Technology Commission
内容类型	期刊论文
源URL	[http://ir.ipe.ac.cn/handle/122111/40467]
专题	中国科学院过程工程研究所
通讯作者	Li, Xiaoyu; Zhang, Xueji; Du, Xin
作者单位	1.Chinese Acad Sci, Inst Proc Engn, Natl Engn Lab Hydromet Cleaner Prod Technol, Key Lab Green Proc & Engn, Beijing 100190, Peoples R China 2.Univ Sci & Technol Beijing, Res Ctr Bioengn & Sensing Technol, Dept Chem & Biol Engn, Beijing 100083, Peoples R China
推荐引用方式 GB/T 7714	Zhou, Mengyun,Xing, Yi,Li, Weike,et al. Thioether-bridged mesoporous organosilica nanocapsules with weak acid-triggered charge reversal for drug delivery[J]. MICROPOROUS AND MESOPOROUS MATERIALS,2020,302:10.
APA	Zhou, Mengyun,Xing, Yi,Li, Weike,Li, Xiaoyu,Zhang, Xueji,&Du, Xin.(2020).Thioether-bridged mesoporous organosilica nanocapsules with weak acid-triggered charge reversal for drug delivery.MICROPOROUS AND MESOPOROUS MATERIALS,302,10.
MLA	Zhou, Mengyun,et al."Thioether-bridged mesoporous organosilica nanocapsules with weak acid-triggered charge reversal for drug delivery".MICROPOROUS AND MESOPOROUS MATERIALS 302(2020):10.