Nano-Fragrance with pH-Sensitive Release Property for Improvement of Central Nervous System

doi:10.1166/jbn.2020.2873

	Nano-Fragrance with pH-Sensitive Release Property for Improvement of Central Nervous System
	Wang, Xiangyu 1,2; Lu, Zhiguo 2,3; Shen, Jie 2,3; Niu, Yunwei 4,6; Xiao, Zuobing 4,6; Chen, Lei 5; Hao, Jifu 1; Zhang, Xin 2
刊名	JOURNAL OF BIOMEDICAL NANOTECHNOLOGY
	2020-02-01
卷号	16 期号:2 页码:193-200
关键词	Aromatic Therapy Nano-Fragrance pH-Sensitive Release Property Silk Improvement of Central Nervous System
ISSN号	1550-7033
DOI	10.1166/jbn.2020.2873
英文摘要	Fragrance has the function of nerve regulation and is widely used in aromatic therapy. However, the rapid release of fragrance can cause discomfort in the body and have side effects. Besides, fragrance is still released when not in use, which can reduce the service life of fragrance products and limit their application. Herein, cationic nanoparticles loaded with linalool were prepared and then adhered on the silk. The fragrance-encapsulated nanoparticles have pH-sensitive release property. Linalool was promoted to release in acidic condition and was suppressed to release in alkaline condition. In addition, the nano-fragrance with controlled release properties had regulatory effects on the central nervous system. It had the effect of relieving stress according to the open field tests. Besides, it increased the expression levels of dopamine, acetylcholine and GABA according to results of liquid chromatograph-mass spectrometer. Therefore, these cationic nano-fragrance with pH-sensitive release property have the potential for aromatherapy.
资助项目	National High Technology Research and Development Program[2016YFA0200303] ; Beijing Natural Science Foundation[L172046] ; Beijing Natural Science Foundation[2192057] ; National Natural Science Foundation of China[31771095] ; National Natural Science Foundation of China[21875254] ; National Natural Science Foundation of China[51573188] ; Beijing Municipal Science and Technology Commission[Z161100002616015]
WOS关键词	DRUG-DELIVERY ; MICELLES ; DISEASE ; NANOTUBES ; LIPOSOMES ; LINKAGES ; ANXIETY ; ABILITY
WOS研究方向	Science & Technology - Other Topics ; Materials Science
语种	英语
出版者	AMER SCIENTIFIC PUBLISHERS
WOS记录号	WOS:000524973800005
资助机构	National High Technology Research and Development Program ; Beijing Natural Science Foundation ; National Natural Science Foundation of China ; Beijing Municipal Science and Technology Commission
内容类型	期刊论文
源URL	[http://ir.ipe.ac.cn/handle/122111/40009]
专题	中国科学院过程工程研究所
通讯作者	Chen, Lei; Hao, Jifu; Zhang, Xin
作者单位	1.Shandong First Med Univ & Shandong Acad Med Sci, Sch Pharmaceut Sci, Tai An 271016, Shandong, Peoples R China 2.Chinese Acad Sci, Inst Proc Engn, State Key Lab Biochem Engn, Beijing 100190, Peoples R China 3.Univ Chinese Acad Sci, Sch Chem Engn, Beijing 100049, Peoples R China 4.Shanghai Res Inst Fragrance & Flavor Ind, Shanghai 200232, Peoples R China 5.Chinese PLA Peoples Liberat Army Gen Hosp, Med Ctr 6, Dept Obstet & Gynecol, Beijing 100048, Peoples R China 6.Shanghai Inst Technol, Sch Perfume & Aroma Technol, Shanghai 200233, Peoples R China
推荐引用方式 GB/T 7714	Wang, Xiangyu,Lu, Zhiguo,Shen, Jie,et al. Nano-Fragrance with pH-Sensitive Release Property for Improvement of Central Nervous System[J]. JOURNAL OF BIOMEDICAL NANOTECHNOLOGY,2020,16(2):193-200.
APA	Wang, Xiangyu.,Lu, Zhiguo.,Shen, Jie.,Niu, Yunwei.,Xiao, Zuobing.,...&Zhang, Xin.(2020).Nano-Fragrance with pH-Sensitive Release Property for Improvement of Central Nervous System.JOURNAL OF BIOMEDICAL NANOTECHNOLOGY,16(2),193-200.
MLA	Wang, Xiangyu,et al."Nano-Fragrance with pH-Sensitive Release Property for Improvement of Central Nervous System".JOURNAL OF BIOMEDICAL NANOTECHNOLOGY 16.2(2020):193-200.