Targeted photodynamic therapy with a novel photosensitizer cercosporin encapsulated multifunctional copolymer

doi:10.1016/j.colsurfa.2019.124136

	Targeted photodynamic therapy with a novel photosensitizer cercosporin encapsulated multifunctional copolymer
	Ye, Zhou 2; Hua, Dong 4; Rao, Yijian 2; Bai, Shuo 5; Seeberger, Peter H.1; Yin, Jian 2; Hu, Jing 3
刊名	COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
	2020-01-20
卷号	585 页码:8
关键词	Cercosporin Multifunctional copolymer Targeted photodynamic therapy Photosensitizer
ISSN号	0927-7757
DOI	10.1016/j.colsurfa.2019.124136
英文摘要	Photoactivated perylenequinones are photosensitizers that transfer into reactive oxygen species with light energy for photodynamic therapy (PDT). Novel photoactivated perylenequinones photosensitizers are of current interest for application in PDT. Cercosporin, a new photoactivated perylenequinone photosensitizer, was encapsulated into multifunctional copolymer for targeting hepatocellular carcinoma cells to give enhanced PDT efficiency. The cercosporin encapsulated multifunctional copolymer exhibited higher targeting ability and better PDT efficiency to HepG2 cells compared with non-targeting copolymer system. Z-stack technique was used to monitor the cytoplasm distribution of cercosporin. The multifunctional copolymer can release cercosporin only in acidic tumor microenvironment to induce a PDT effect and realize the tracking ability thanks to covalent binding with rhodamine B. The cercosporin encapsulated multifunctional copolymer holds great potential in PDT for cancer treatment.
资助项目	National Natural Science Foundation of China[31700706] ; National Natural Science Foundation of China[21877052] ; Natural Science Foundation of Jiangsu Province[BK20180030] ; Fundamental Research Funds for the Central Universities[JUSRP51712B] ; Max Planck Society International Partner Group Program ; High-end Foreign Experts Recruitment Program ; Thousand Talents Plan (Young Professionals) ; China Scholarship Council
WOS关键词	SINGLET OXYGEN ; RADICAL POLYMERIZATION ; RHODAMINE-B ; DERIVATIVES ; EFFICIENT ; MICELLES
WOS研究方向	Chemistry
语种	英语
出版者	ELSEVIER
WOS记录号	WOS:000502046200069
资助机构	National Natural Science Foundation of China ; Natural Science Foundation of Jiangsu Province ; Fundamental Research Funds for the Central Universities ; Max Planck Society International Partner Group Program ; High-end Foreign Experts Recruitment Program ; Thousand Talents Plan (Young Professionals) ; China Scholarship Council
内容类型	期刊论文
源URL	[http://ir.ipe.ac.cn/handle/122111/38445]
专题	中国科学院过程工程研究所
通讯作者	Yin, Jian; Hu, Jing
作者单位	1.Max Planck Inst Colloids & Interfaces, Dept Biomol Syst, Muhlenberg 1, D-14476 Potsdam, Germany 2.Jiangnan Univ, Sch Biotechnol, Minist Educ, Key Lab Carbohydrate Chem & Biotechnol, Wuxi 214122, Jiangsu, Peoples R China 3.Jiangnan Univ, Wuxi Sch Med, Wuxi 214122, Jiangsu, Peoples R China 4.Jiangnan Univ, Affiliated Hosp, Wuxi 214122, Jiangsu, Peoples R China 5.Chinese Acad Sci, Inst Proc Engn, Beijing 100190, Peoples R China
推荐引用方式 GB/T 7714	Ye, Zhou,Hua, Dong,Rao, Yijian,et al. Targeted photodynamic therapy with a novel photosensitizer cercosporin encapsulated multifunctional copolymer[J]. COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS,2020,585:8.
APA	Ye, Zhou.,Hua, Dong.,Rao, Yijian.,Bai, Shuo.,Seeberger, Peter H..,...&Hu, Jing.(2020).Targeted photodynamic therapy with a novel photosensitizer cercosporin encapsulated multifunctional copolymer.COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS,585,8.
MLA	Ye, Zhou,et al."Targeted photodynamic therapy with a novel photosensitizer cercosporin encapsulated multifunctional copolymer".COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS 585(2020):8.