Nanomedicine Strategies to Circumvent Intratumor Extracellular Matrix Barriers for Cancer Therapy

doi:10.1002/adhm.202101428

	Nanomedicine Strategies to Circumvent Intratumor Extracellular Matrix Barriers for Cancer Therapy
	Xu, Xiaoxuan 1,2,3; Wu, Yao 1,2; Qian, Xindi 1,2,3; Wang, Yuqi 1,2; Wang, Jiaoying 1,2; Li, Jie 1,2; Li, Yaping 1,2,3; Zhang, Zhiwen 1,2,3,4
刊名	ADVANCED HEALTHCARE MATERIALS
	2021-11-10
页码	25
关键词	cancer therapy drug delivery extracellular matrix nanomedicine tumor penetration
ISSN号	2192-2640
DOI	10.1002/adhm.202101428
通讯作者	Zhang, Zhiwen(zwzhang0125@simm.ac.cn)
英文摘要	The dense and heterogeneous physical network of the extracellular matrix (ECM) in tumors represents a formidable barrier that limits intratumor drug delivery and the therapeutic efficacy of many anticancer therapies. Here, the two major nanomedicine strategies to circumvent intratumor ECM barriers: regulating the physiochemical properties of nanomedicines and remodeling the components and structure of the ECM are summarized. Nanomedicines can be rationally regulated by optimizing physiochemical properties or designed with biomimetic features to promote ECM permeation capability. Meanwhile, they can also be designed to remodel the ECM by modulating signaling pathways or destroying the components and architecture of the ECM via chemical, biological, or physical treatments. These efforts produce profound improvements in intratumor drug delivery and anticancer efficacy. Moreover, to aid in their anticancer efficacy, feasible approaches for improving ECM-circumventing nanomedicines are proposed.
资助项目	National Natural Science Foundation of China[32071385] ; National Natural Science Foundation of China[31771092] ; National Natural Science Foundation of China[31930066] ; Shandong Provincial Natural Science Foundation of China[ZR2019ZD25] ; Fudan-SIMM Joint Research Fund[FU-SIMM20182005]
WOS关键词	TUMOR-TARGETING EFFICIENCY ; PANCREATIC-CANCER ; IN-VIVO ; LUNG METASTASIS ; DRUG-DELIVERY ; NANOPARTICLES ; PENETRATION ; MICROENVIRONMENT ; BREAST ; CELL
WOS研究方向	Engineering ; Science & Technology - Other Topics ; Materials Science
语种	英语
出版者	WILEY
WOS记录号	WOS:000716812100001
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/298704]
专题	中国科学院上海药物研究所
通讯作者	Zhang, Zhiwen
作者单位	1.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Mat Med, Ctr Pharmaceut, Shanghai 201203, Peoples R China 3.Univ Chinese Acad Sci, Sch Pharm, 19A Yuqian Rd, Beijing 100049, Peoples R China 4.Yantai Inst Mat Med, Yantai Key Lab Nanomed & Adv Preparat, Yantai 264000, Shandong, Peoples R China
推荐引用方式 GB/T 7714	Xu, Xiaoxuan,Wu, Yao,Qian, Xindi,et al. Nanomedicine Strategies to Circumvent Intratumor Extracellular Matrix Barriers for Cancer Therapy[J]. ADVANCED HEALTHCARE MATERIALS,2021:25.
APA	Xu, Xiaoxuan.,Wu, Yao.,Qian, Xindi.,Wang, Yuqi.,Wang, Jiaoying.,...&Zhang, Zhiwen.(2021).Nanomedicine Strategies to Circumvent Intratumor Extracellular Matrix Barriers for Cancer Therapy.ADVANCED HEALTHCARE MATERIALS,25.
MLA	Xu, Xiaoxuan,et al."Nanomedicine Strategies to Circumvent Intratumor Extracellular Matrix Barriers for Cancer Therapy".ADVANCED HEALTHCARE MATERIALS (2021):25.