The potent radioprotective agents: Novel nitronyl nitroxide radical spin-labeled resveratrol derivatives

doi:10.1016/j.fitote.2021.105053

	The potent radioprotective agents: Novel nitronyl nitroxide radical spin-labeled resveratrol derivatives
	Luo, Guoying 1,2; Sun, Lanlan 3; Li, Heng 3,4; Chen, Jia 1,2; He, Peilan 3; Zhao, Liang 1,2; Tang, Wei 3,4; Qiu, Hongdeng 1,2
刊名	FITOTERAPIA
	2021-11-01
卷号	155 页码:7
关键词	Ionizing radiation Resveratrol Nitronyl nitroxide radical Radioprotection effects
ISSN号	0367-326X
DOI	10.1016/j.fitote.2021.105053
通讯作者	Chen, Jia(jiachen@licp.cas.cn) ; Tang, Wei(tangwei@simm.ac.cn)
英文摘要	It is commonly known that radiotherapy is still a key modality for treatment of cancer. Though this effect is desirable during radiotherapy, it leads to radiotoxicity on normal healthy cells. In the present research, we designed, synthesized and analyzed a series of nitronyl nitroxide radical (NITR) spin-labeled resveratrol (RES) derivatives. The cytotoxicity of the newly synthesized substances was tested on Jurkat T cells. The derivatives were studied as reactive oxygen species (ROS) scavenger to protect ionizing radiation of Jurkat T cells upon 6 Gy X-irradiation. The experimental results revealed that compound 2 and 3 could significantly alleviate the damage of Jurkat T cells, as evidenced by decreasing ROS production and restoring the cell apoptosis. Further mechanism investigations indicated that the radioprotective effects of the novel derivatives were largely associated with modulating the expression of apoptotic proteins including cIAP-1, cIAP-2, cytochrome c, caspase-3 and caspase9. Based on the experimental result, we disclosed that the novel NITR spin-labeled RES derivatives exhibit the potential to be used as the novel radioprotective candidates to ameliorate the injury induced by ionizing radiation.
WOS关键词	PHARMACOKINETICS ; CAMPTOTHECIN ; MECHANISMS ; EXPRESSION ; AMIFOSTINE ; CHEMISTRY ; RADIATION ; TOXICITY ; DESIGN ; DAMAGE
WOS研究方向	Pharmacology & Pharmacy
语种	英语
出版者	ELSEVIER
WOS记录号	WOS:000710100600002
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/298469]
专题	中国科学院上海药物研究所
通讯作者	Chen, Jia; Tang, Wei
作者单位	1.Chinese Acad Sci, Lanzhou Inst Chem Phys, CAS Key Lab Chem Northwestern Plant Resources, Lanzhou 730000, Peoples R China 2.Chinese Acad Sci, Lanzhou Inst Chem Phys, Key Lab Nat Med Gansu Prov, Lanzhou 730000, Peoples R China 3.Chinese Acad Sci, Shanghai Inst Mat Med, Lab Antiinflammat & Immunopharmacol, Shanghai 201203, Peoples R China 4.Univ Chinese Acad Sci, Sch Pharm, Beijing 100049, Peoples R China
推荐引用方式 GB/T 7714	Luo, Guoying,Sun, Lanlan,Li, Heng,et al. The potent radioprotective agents: Novel nitronyl nitroxide radical spin-labeled resveratrol derivatives[J]. FITOTERAPIA,2021,155:7.
APA	Luo, Guoying.,Sun, Lanlan.,Li, Heng.,Chen, Jia.,He, Peilan.,...&Qiu, Hongdeng.(2021).The potent radioprotective agents: Novel nitronyl nitroxide radical spin-labeled resveratrol derivatives.FITOTERAPIA,155,7.
MLA	Luo, Guoying,et al."The potent radioprotective agents: Novel nitronyl nitroxide radical spin-labeled resveratrol derivatives".FITOTERAPIA 155(2021):7.