Construction of bio-functional Mg/HA composite layered coating for orthopedic application

doi:10.1007/s11431-020-1762-3

CORC > 金属研究所 > 中国科学院金属研究所

	Construction of bio-functional Mg/HA composite layered coating for orthopedic application
	Wan Peng 1,2; Yan Xudong 3; Li Mei 4; Zhao Mingchun 3; Zhang Yu 4; Yang Ke 2
刊名	SCIENCE CHINA-TECHNOLOGICAL SCIENCES
	2021-09-26
页码	10
关键词	magnesium HA composite layered coating titanium orthopedic bio-function
ISSN号	1674-7321
DOI	10.1007/s11431-020-1762-3
通讯作者	Wan Peng(wanpeng@dgut.edu.cn) ; Yang Ke(kyang@imr.ac.cn)
英文摘要	Magnesium was considered as a revolutionary biodegradable implant material for orthopedic application. Concerning the weakness of intrinsic strength and corrosion behavior, a novel strategy of Mg/metal hybrid system was proposed for extension of orthopedic application, especially at load-bearing site. In this work, an Mg and HA composite layered coating was constructed on titanium by means of chemical conversion and vapor deposition. The HA transition interlayer was introduced to enhance the bonding between Mg film and Ti substrate. Compared with the bare Mg coating, the Mg/HA coating presented good interface bonding, which avoided the occurrence of Mg film peeling off from the substrate. The Mg/HA coating showed a uniform degradation and kept integrity after immersion of 14 d. The Mg ions release by degradation played a crucial role in osteopromotion and antibacterial effect. Incubation of MC3T3-E1 osteoblasts with the Mg/HA coating showed significant promotion on osteogenic differentiation according to ALP activity and Alizarin Red staining assays. Meanwhile the degradation of Mg exhibited strong suppression of bacteria proliferation. It was believed that this novel Mg/HA composite layered coating could be potentially applied in further development of bio-functional hybrid orthopedic implants.
资助项目	National Natural Science Foundation of China[31500777] ; Research Start-up Funds of DGUT[GC300501-082] ; Characteristic Innovation Project of University in Guangdong[2020KTSCX148]
WOS研究方向	Engineering ; Materials Science
语种	英语
出版者	SCIENCE PRESS
WOS记录号	WOS:000702976900001
资助机构	National Natural Science Foundation of China ; Research Start-up Funds of DGUT ; Characteristic Innovation Project of University in Guangdong
内容类型	期刊论文
源URL	[http://ir.imr.ac.cn/handle/321006/166699]
专题	金属研究所_中国科学院金属研究所
通讯作者	Wan Peng; Yang Ke
作者单位	1.Dongguan Univ Technol, Sch Mat Sci & Engn, Dongguan 523808, Peoples R China 2.Chinese Acad Sci, Inst Met Res, Shenyang 110016, Peoples R China 3.Cent South Univ, Sch Mat Sci & Engn, Changsha 410083, Peoples R China 4.Guangdong Prov Peoples Hosp, Guangdong Acad Med Sci, Res Ctr Med Sci, Guangzhou 510080, Peoples R China
推荐引用方式 GB/T 7714	Wan Peng,Yan Xudong,Li Mei,et al. Construction of bio-functional Mg/HA composite layered coating for orthopedic application[J]. SCIENCE CHINA-TECHNOLOGICAL SCIENCES,2021:10.
APA	Wan Peng,Yan Xudong,Li Mei,Zhao Mingchun,Zhang Yu,&Yang Ke.(2021).Construction of bio-functional Mg/HA composite layered coating for orthopedic application.SCIENCE CHINA-TECHNOLOGICAL SCIENCES,10.
MLA	Wan Peng,et al."Construction of bio-functional Mg/HA composite layered coating for orthopedic application".SCIENCE CHINA-TECHNOLOGICAL SCIENCES (2021):10.