Polymorphism of Transferrin Gene Impacts the Mediating Effects of Psychotic Symptoms on the Relationship between Oxidative Stress and Cognition in Patients with Chronic Schizophrenia | |
Chen, Pinhong3; Wang, Dongmei1,2; Xiu, Meihong5; Chen, Dachun5; Lackey, Blake4; Wu, Hanjing E.4; Zhou, Jin3; Zhang, Xiangyang1,2 | |
刊名 | ANTIOXIDANTS |
2022 | |
卷号 | 11期号:1页码:11 |
关键词 | transferrin polymorphism oxidative stress psychotic symptoms cognitive function schizophrenia |
DOI | 10.3390/antiox11010125 |
产权排序 | 2 |
文献子类 | 实证研究 |
英文摘要 | A series of studies indicated that iron distribution that partly derives from transferrin-bound iron in the peripheral nervous system in the brain may act in processes such as myelination and brain development. However, the relationship between schizophrenia, its psychotic symptoms, and the transferrin (TF) gene has not been systematically explored. Our study aimed to investigate how a particular polymorphism of the transferrin gene, rs3811655, affects the superoxide dismutase (SOD), malondialdehyde (MDA), psychotic symptoms, cognition, or the mediation model between antioxidant enzymes and cognition via symptoms. A total of 564 patients with chronic schizophrenia and 468 healthy control subjects were recruited. The psychotic symptoms and cognition were assessed by the Positive and Negative Syndrome Scale (PANSS) and the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS), respectively. Furthermore, the serum SOD, MDA activity, and transferrin gene polymorphism were measured in patients. Our results demonstrated that patients with the G allele possessed more severe negative symptoms, worse cognitive performance with respect to attention, and higher serum Mn-SOD activity. Additionally, the rs3811655 polymorphism may act as a moderator in the association between Cu/Zn-SOD activity and cognition, as well as psychotic symptoms in patients suffering from schizophrenia. According to this study, the single nucleotide polymorphism (SNP) rs3811655 polymorphism may fail to contribute to the susceptibility of schizophrenia in an individual but is involved in the iron-induced oxidative stress disturbance and cognitive impairment in schizophrenia. This deepens our understanding of the critical role of iron-induced oxidative stress that might underlie the pathophysiology of schizophrenia. |
收录类别 | SCI |
WOS关键词 | SUPEROXIDE-DISMUTASE ; ASSOCIATION ; IMPAIRMENT ; METAANALYSIS ; MARKERS |
WOS研究方向 | Biochemistry & Molecular Biology ; Pharmacology & Pharmacy ; Food Science & Technology |
语种 | 英语 |
出版者 | MDPI |
WOS记录号 | WOS:000747439600001 |
内容类型 | 期刊论文 |
源URL | [http://ir.psych.ac.cn/handle/311026/41878] |
专题 | 心理研究所_中国科学院心理健康重点实验室 |
通讯作者 | Zhou, Jin; Zhang, Xiangyang |
作者单位 | 1.Univ Chinese Acad Sci, Dept Psychol, Beijing 100101, Peoples R China 2.Inst Psychol, CAS Key Lab Mental Hlth, Beijing 100101, Peoples R China 3.Beijing Inst Basic Med Sci, Beijing 100850, Peoples R China 4.Univ Texas Hlth Sci Ctr Houston, Dept Psychiat & Behav Sci, Houston, TX 77030 USA 5.Peking Univ, Beijing HuiLongGuan Hosp, Beijing 100096, Peoples R China |
推荐引用方式 GB/T 7714 | Chen, Pinhong,Wang, Dongmei,Xiu, Meihong,et al. Polymorphism of Transferrin Gene Impacts the Mediating Effects of Psychotic Symptoms on the Relationship between Oxidative Stress and Cognition in Patients with Chronic Schizophrenia[J]. ANTIOXIDANTS,2022,11(1):11. |
APA | Chen, Pinhong.,Wang, Dongmei.,Xiu, Meihong.,Chen, Dachun.,Lackey, Blake.,...&Zhang, Xiangyang.(2022).Polymorphism of Transferrin Gene Impacts the Mediating Effects of Psychotic Symptoms on the Relationship between Oxidative Stress and Cognition in Patients with Chronic Schizophrenia.ANTIOXIDANTS,11(1),11. |
MLA | Chen, Pinhong,et al."Polymorphism of Transferrin Gene Impacts the Mediating Effects of Psychotic Symptoms on the Relationship between Oxidative Stress and Cognition in Patients with Chronic Schizophrenia".ANTIOXIDANTS 11.1(2022):11. |
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