CanImmunother: a manually curated database for identification of cancer immunotherapies associating with biomarkers, targets, and clinical effects

doi:10.1080/2162402X.2021.1944553

	CanImmunother: a manually curated database for identification of cancer immunotherapies associating with biomarkers, targets, and clinical effects
	Zhang, Wenliang 2,3,4; Zeng, Binghui 5; Lin, Huancai 5; Guan, Wen 4,6; Mo, Jing 4; Wu, Song 7; Wei, Yanjie 3,8,9; Zhang, Qianshen 2; Yu, Dongsheng 5; Li, Weizhong 1,7,10
刊名	ONCOIMMUNOLOGY
	2021
卷号	10 期号:1 页码:12
关键词	Cancer immunotherapy immune checkpoint database biomarker tumor vaccine
ISSN号	2162-402X
DOI	10.1080/2162402X.2021.1944553
英文摘要	As immunotherapy is evolving into an essential armamentarium against cancers, numerous translational studies associated with relevant biomarkers, targets, and clinical effects have been reported in recent years. However, a large amount of associated experimental data remains unexplored due to the difficulty in accessibility and utilization. Here, we established a comprehensive high-quality database for cancer immunotherapy called CanImmunother (http://www.biomedical-web.com/cancerit/) through manual curation on 4515 publications. CanImmunother contains 3267 experimentally validated associations between 218 cancer sub-types across 34 body parts and 484 immunotherapies with 642 biomarkers, 108 targets, and 121 control therapies. Each association was manually curated by professional curators, incorporated with valuable annotation and cross references, and assigned with an association score for prioritization. To help clinicians and researchers in identifying and discovering better cancer immunotherapy and their respective biomarkers and targets, CanImmunother offers user-friendly web applications including search, browse, excel table, association prioritization, and network visualization. CanImmunother presents a landscape of experimental cancer immunotherapy association data, serving as a useful resource to improve our insight and to facilitate further discovery of advanced immunotherapy options for cancer patients.
资助项目	Guangdong Basic and Applied Basic Research Foundation, China[2020A1515110528] ; China Postdoctoral Science Foundation[2020M673023] ; China Postdoctoral Science Foundation[2021M693302] ; Strategic Priority CAS Project[XDB38000000] ; National Key R&D Program of China[2018YFB0204403] ; National Key R&D Program of China[2018YFC0910401] ; National Key R&D Program of China[2016YFC0901604] ; Shenzhen Basic Research Fund[RCYX2020071411473419] ; Shenzhen Basic Research Fund[JCYJ20170413093358429] ; Natural Science Foundation of Guangdong Province[2021A1515012108] ; Guangdong Project[2017GC010608] ; Support Scheme of Guangzhou for Leading Talents in Innovation and Entrepreneurship[2020007] ; National Natural Science Foundation of China[81873711] ; Fundamental Research Funds of the Central Universities, Sun Yat-sen University[19ykpy86] ; Sanming Project of Medicine (Shenzhen)[SZSM201911016]
WOS研究方向	Oncology ; Immunology
语种	英语
出版者	TAYLOR & FRANCIS INC
WOS记录号	WOS:000674116500001
内容类型	期刊论文
源URL	[http://119.78.100.204/handle/2XEOYT63/17459]
专题	中国科学院计算技术研究所
通讯作者	Zhang, Wenliang; Yu, Dongsheng; Li, Weizhong; Chan, Godfrey Chi-Fung
作者单位	1.Sun Yat Sen Univ, Ctr Precis Med, Guangzhou, Peoples R China 2.Univ Hong Kong, Dept Pediat, Shenzhen Hosp, Shenzhen 518058, Peoples R China 3.Chinese Acad Sci, Shenzhen Inst Adv Technol, Shenzhen, Guangdong, Peoples R China 4.Outstanding Biotechnol Co Ltd, Dept Bioinformat, Shenzhen, Peoples R China 5.Sun Yat Sen Univ, Hosp Stomatol, Guanghua Sch Stomatol, Guangdong Prov Key Lab Stomatol, Guangzhou 510055, Peoples R China 6.Guangdong Acad Sci, Inst Zool, Guangdong Key Lab Anim Conservat & Resource Utili, Guangzhou, Peoples R China 7.Sun Yat Sen Univ, Zhongshan Sch Med, Guangzhou 510080, Peoples R China 8.Chinese Acad Sci, Ctr High Performance Comp, Shenzhen Inst Adv Technol, Shenzhen, Guangdong, Peoples R China 9.Chinese Acad Sci, Shenzhen Inst Adv Technol, CAS Key Lab Hlth Informat, Shenzhen, Guangdong, Peoples R China 10.Sun Yat Sen Univ, Key Lab Trop Dis Control, Minist Educ, Guangzhou, Peoples R China
推荐引用方式 GB/T 7714	Zhang, Wenliang,Zeng, Binghui,Lin, Huancai,et al. CanImmunother: a manually curated database for identification of cancer immunotherapies associating with biomarkers, targets, and clinical effects[J]. ONCOIMMUNOLOGY,2021,10(1):12.
APA	Zhang, Wenliang.,Zeng, Binghui.,Lin, Huancai.,Guan, Wen.,Mo, Jing.,...&Chan, Godfrey Chi-Fung.(2021).CanImmunother: a manually curated database for identification of cancer immunotherapies associating with biomarkers, targets, and clinical effects.ONCOIMMUNOLOGY,10(1),12.
MLA	Zhang, Wenliang,et al."CanImmunother: a manually curated database for identification of cancer immunotherapies associating with biomarkers, targets, and clinical effects".ONCOIMMUNOLOGY 10.1(2021):12.