Genetic Continuity of Bronze Age Ancestry with Increased Steppe-Related Ancestry in Late Iron Age Uzbekistan

doi:10.1093/molbev/msab216

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	Genetic Continuity of Bronze Age Ancestry with Increased Steppe-Related Ancestry in Late Iron Age Uzbekistan
	Kumar, Vikas 5,6; Bennett, E. Andrew 6; Zhao, Dongyue 4; Liang, Yun 4; Tang, Yunpeng 4; Ren, Meng 4; Dai, Qinyan 6; Feng, Xiaotian 6; Cao, Peng 6; Yang, Ruowei 6
刊名	MOLECULAR BIOLOGY AND EVOLUTION
	2021-11-01
卷号	38 期号:11 页码:4908-4917
关键词	ancient DNA population genomics evolution
ISSN号	0737-4038
DOI	10.1093/molbev/msab216
通讯作者	Muttalib, Hasanov(khasanov.mutalib@mail.ru) ; Wang, Jianxin(moguwang@nwu.edu.cn) ; Fu, Qiaomei(fuqiaomei@ivpp.ac.cn)
英文摘要	Although Uzbekistan and Central Asia are known for the well-studied Bronze Age civilization of the Bactria-Margiana Archaeological Complex (BMAC), the lesser-known Iron Age was also a dynamic period that resulted in increased interaction and admixture among different cultures from this region. To broaden our understanding of events that impacted the demography and population structure of this region, we generated 27 genome-wide single-nucleotide polymorphism capture data sets of Late Iron Age individuals around the Historical Kushan time period (similar to 2100-1500 BP) from three sites in South Uzbekistan. Overall, Bronze Age ancestry persists into the Iron Age in Uzbekistan, with no major replacements of populations with Steppe-related ancestry. However, these individuals suggest diverse ancestries related to Iranian farmers, Anatolian farmers, and Steppe herders, with a small amount of West European Hunter Gatherer, East Asian, and South Asian Hunter Gatherer ancestry as well. Genetic affinity toward the Late Bronze Age Steppe herders and a higher Steppe-related ancestry than that found in BMAC populations suggest an increased mobility and interaction of individuals from the Northern Steppe in a Southward direction. In addition, a decrease of Iranian and an increase of Anatolian farmer-like ancestry in Uzbekistan Iron Age individuals were observed compared with the BMAC populations from Uzbekistan. Thus, despite continuity from the Bronze Age, increased admixture played a major role in the shift from the Bronze to the Iron Age in southern Uzbekistan. This mixed ancestry is also observed in other parts of the Steppe and Central Asia, suggesting more widespread admixture among local populations.
资助项目	National Key R&D Program of China[2016YFE0203700] ; Chinese Academy of Sciences (CAS)[XDB26000000] ; National Natural Science Foundation of China[91731303] ; National Natural Science Foundation of China[41925009] ; National Natural Science Foundation of China[41630102] ; Chinese Academy of Sciences[XDA1905010] ; Chinese Academy of Sciences[QYZDB-SSW-DQC003] ; Tencent Foundation through the XPLORER PRIZE ; Howard Hughes Medical Institute[55008731]
WOS关键词	ANCIENT HUMAN GENOMES ; POPULATION-STRUCTURE ; SEQUENCE ; DIVERSITY ; MIGRATION ; ADMIXTURE ; ORIGIN ; CAVE ; ASIA
WOS研究方向	Biochemistry & Molecular Biology ; Evolutionary Biology ; Genetics & Heredity
语种	英语
出版者	OXFORD UNIV PRESS
WOS记录号	WOS:000715560700018
资助机构	National Key R&D Program of China ; Chinese Academy of Sciences (CAS) ; National Natural Science Foundation of China ; Chinese Academy of Sciences ; Tencent Foundation through the XPLORER PRIZE ; Howard Hughes Medical Institute
内容类型	期刊论文
源URL	[http://119.78.100.205/handle/311034/19068]
专题	古脊椎动物与古人类研究所_图书馆1
通讯作者	Muttalib, Hasanov; Wang, Jianxin; Fu, Qiaomei
作者单位	1.Acad Sci Uzbek, Inst Archaeol, Samarkand, Uzbekistan 2.Univ Richmond, Dept Biol, Richmond, VA 23173 USA 3.Univ Chinese Acad Sci, Beijing, Peoples R China 4.Northwest Univ, Sch Cultural Heritage, Xian, Peoples R China 5.Shanghai Qi Zhi Inst, Shanghai 200232, Peoples R China 6.Chinese Acad Sci, Ctr Excellence Life & Paleoenvironm, Inst Vertebrate Paleontol & Paleoanthropol, Key Lab Vertebrate Evolut & Human Origins, Beijing, Peoples R China
推荐引用方式 GB/T 7714	Kumar, Vikas,Bennett, E. Andrew,Zhao, Dongyue,et al. Genetic Continuity of Bronze Age Ancestry with Increased Steppe-Related Ancestry in Late Iron Age Uzbekistan[J]. MOLECULAR BIOLOGY AND EVOLUTION,2021,38(11):4908-4917.
APA	Kumar, Vikas.,Bennett, E. Andrew.,Zhao, Dongyue.,Liang, Yun.,Tang, Yunpeng.,...&Fu, Qiaomei.(2021).Genetic Continuity of Bronze Age Ancestry with Increased Steppe-Related Ancestry in Late Iron Age Uzbekistan.MOLECULAR BIOLOGY AND EVOLUTION,38(11),4908-4917.
MLA	Kumar, Vikas,et al."Genetic Continuity of Bronze Age Ancestry with Increased Steppe-Related Ancestry in Late Iron Age Uzbekistan".MOLECULAR BIOLOGY AND EVOLUTION 38.11(2021):4908-4917.