Preparative purification of polyethylene glycol derivatives with polystyrene-divinylbenzene beads as chromatographic packing

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	Preparative purification of polyethylene glycol derivatives with polystyrene-divinylbenzene beads as chromatographic packing
	Yu, Pengzhan ; Li, Xingqi ; Li, Xiunan ; Lu, Xiuling ; Ma, Guanghui ; Su, Zhiguo
刊名	BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
	2007-10-15
卷号	17 期号:20 页码:5605-5609
关键词	polystyrene-divinyl benzene beads purification of polyethylene glycol derivatives preparative reversed-phase chromatography
ISSN号	0960-894X
其他题名	Bioorg. Med. Chem. Lett.
中文摘要	A clear and powerful chromatographic approach to purify polyethylene glycol derivatives at a preparative scale was reported, which was based on the polystyrene-divinylbenzene beads with ethanol/water as eluants. The validity of this method was verified with the reaction mixture of mPEG-Glu and mPEG propionaldehyde diethylacetal (ALD-PEG) as the model. The target products were one-step achieved with the purity of > 99% on the polymer resins column at gram scale. The method developed was free from such disadvantages as utility of toxic solvent and narrow application scope, which was combined with conventional approaches. The method developed provided an appealing and attractive alternative methods for purification of PEG derivatives at a preparative scale. (c) 2007 Elsevier Ltd. All rights reserved.
英文摘要	A clear and powerful chromatographic approach to purify polyethylene glycol derivatives at a preparative scale was reported, which was based on the polystyrene-divinylbenzene beads with ethanol/water as eluants. The validity of this method was verified with the reaction mixture of mPEG-Glu and mPEG propionaldehyde diethylacetal (ALD-PEG) as the model. The target products were one-step achieved with the purity of > 99% on the polymer resins column at gram scale. The method developed was free from such disadvantages as utility of toxic solvent and narrow application scope, which was combined with conventional approaches. The method developed provided an appealing and attractive alternative methods for purification of PEG derivatives at a preparative scale. (c) 2007 Elsevier Ltd. All rights reserved.
WOS标题词	Science & Technology ; Life Sciences & Biomedicine ; Physical Sciences
类目[WOS]	Chemistry, Medicinal ; Chemistry, Organic
研究领域[WOS]	Pharmacology & Pharmacy ; Chemistry
关键词[WOS]	POLY(ETHYLENE GLYCOL) ; PROTEIN MODIFICATION ; SITE ; PEGYLATION ; AGENTS ; PEGS
收录类别	SCI
原文出处	://WOS:000250287600023
语种	英语
WOS记录号	WOS:000250287600023
公开日期	2013-10-15
内容类型	期刊论文
版本	出版稿
源URL	[http://ir.ipe.ac.cn/handle/122111/3497]
专题	过程工程研究所_研究所（批量导入）
作者单位	1.Chinese Acad Sci, Inst Proc Engn, Natl Key Lab Biochem Engn, Beijing 100080, Peoples R China 2.Chinese Acad Sci, Grad Univ, Beijing 100039, Peoples R China
推荐引用方式 GB/T 7714	Yu, Pengzhan,Li, Xingqi,Li, Xiunan,et al. Preparative purification of polyethylene glycol derivatives with polystyrene-divinylbenzene beads as chromatographic packing[J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,2007,17(20):5605-5609.
APA	Yu, Pengzhan,Li, Xingqi,Li, Xiunan,Lu, Xiuling,Ma, Guanghui,&Su, Zhiguo.(2007).Preparative purification of polyethylene glycol derivatives with polystyrene-divinylbenzene beads as chromatographic packing.BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,17(20),5605-5609.
MLA	Yu, Pengzhan,et al."Preparative purification of polyethylene glycol derivatives with polystyrene-divinylbenzene beads as chromatographic packing".BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 17.20(2007):5605-5609.