DLEU2 participates in lymphovascular invasion and inhibits cervical cancer cell proliferation, and invasion

	DLEU2 participates in lymphovascular invasion and inhibits cervical cancer cell proliferation, and invasion
	Zhang, Hanqun 1; Wang, Xiaohu 1,3; Zhang, Qiuning 1,2; Ma, Yan 1; Wang, Zi 4
刊名	INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY
	2020
卷号	13 期号:8 页码:2018-2026
关键词	Cervical cancer long non-coding RNA deleted in lymphocytic leukemia 2
ISSN号	1936-2625
通讯作者	Wang, Xiaohu(xhwanggansu@163.com) ; Wang, Zi(wz522321@163.com)
英文摘要	Aims: To investigate the roles of deleted in lymphocytic leukemia-2 (DLEU2) in the pathology of cervical cancer. Methods: Differentially expressed long non-coding RNAs between cervical cancerous and para-cancerous tissues were examined in 26 clinical specimens by microarray analysis and quantitative real-time PCR. DLEU2 ex-pression was correlated with clinical features in 108 patients with cervical cancer. The effects of DLEU2 on growth, proliferation, migration, and invasion were examined in cervical cancer cells. Results: DLEU2 was correlated with lymphovascular invasion in patients with cervical cancer. DLEU2 overexpression inhibited cell proliferation, migra-tion, and proliferation, and colony formation in cervical cancer cells. Conclusion: DLEU2 is involved in the pathology of cervical cancer, and it may be a target for clinical therapy.
资助项目	Guizhou Innovation and Entrepreneurship Foundation for High-level Overseas Talent[[2019] 03] ; National Natural Science Foundation of China[81860535]
WOS关键词	LONG NONCODING RNAS ; CARCINOMA ; EXPRESSION ; 13Q14 ; RISK ; GENE
WOS研究方向	Oncology ; Pathology
语种	英语
出版者	E-CENTURY PUBLISHING CORP
WOS记录号	WOS:000573059000008
资助机构	Guizhou Innovation and Entrepreneurship Foundation for High-level Overseas Talent ; National Natural Science Foundation of China
内容类型	期刊论文
源URL	[http://119.78.100.186/handle/113462/139633]
专题	中国科学院近代物理研究所
通讯作者	Wang, Xiaohu; Wang, Zi
作者单位	1.Lanzhou Univ, Sch Clin Med 1, Lanzhou 730000, Gansu, Peoples R China 2.Chinese Acad Sci, Inst Modern Phys, Lanzhou 730000, Gansu, Peoples R China 3.Gansu Prov Canc Hosp, Lanzhou 730000, Gansu, Peoples R China 4.Guizhou Prov Peoples Hosp, Dept Oncol, Guiyang 550002, Peoples R China
推荐引用方式 GB/T 7714	Zhang, Hanqun,Wang, Xiaohu,Zhang, Qiuning,et al. DLEU2 participates in lymphovascular invasion and inhibits cervical cancer cell proliferation, and invasion[J]. INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY,2020,13(8):2018-2026.
APA	Zhang, Hanqun,Wang, Xiaohu,Zhang, Qiuning,Ma, Yan,&Wang, Zi.(2020).DLEU2 participates in lymphovascular invasion and inhibits cervical cancer cell proliferation, and invasion.INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY,13(8),2018-2026.
MLA	Zhang, Hanqun,et al."DLEU2 participates in lymphovascular invasion and inhibits cervical cancer cell proliferation, and invasion".INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY 13.8(2020):2018-2026.