A Minireview on Gastrointestinal Microbiota and Radiosusceptibility

doi:10.1177/1559325820963859

	A Minireview on Gastrointestinal Microbiota and Radiosusceptibility
	Mao, Aihong 2; Sun, Chao 3; Katsube, Takanori 1; Wang, Bing 1
刊名	DOSE-RESPONSE
	2020-10-01
卷号	18 期号:4 页码:11
关键词	GI microbiota radiation radiosusceptibility immune response microbiota manipulation
ISSN号	1559-3258
DOI	10.1177/1559325820963859
通讯作者	Mao, Aihong(maoaih@impcas.ac.cn) ; Wang, Bing(wang.bing@qst.go.jp)
英文摘要	Gastrointestinal (GI) microbiota maintains a symbiotic relationship with the host and plays a key role in modulating many important biological processes and functions of the host, such as metabolism, inflammation, immune and stress response. It is becoming increasingly apparent that GI microbiota is susceptible to a wide range of environmental factors and insults, for examples, geographic location of birth, diet, use of antibiotics, and exposure to radiation. Alterations in GI microbiota link to various diseases, including radiation-induced disorders. In addition, GI microbiota composition could be used as a biomarker to estimate radiosusceptibility and radiation health risk in the host. In this minireview, we summarized the documented studies on radiation-induced alterations in GI microbiota and the relationship between GI microbiota and radiosusceptibility of the host, and mainly discussed the possible mechanisms underlying GI microbiota influencing the outcome of radiation response in humans and animal models. Furthermore, we proposed that GI microbiota manipulation may be used to reduce radiation injury and improve the health of the host.
资助项目	Japan China Medical Association ; Nippon Foundation, Japan
WOS研究方向	Pharmacology & Pharmacy ; Radiology, Nuclear Medicine & Medical Imaging ; Toxicology
语种	英语
出版者	SAGE PUBLICATIONS INC
WOS记录号	WOS:000593484200001
资助机构	Japan China Medical Association ; Nippon Foundation, Japan
内容类型	期刊论文
源URL	[http://119.78.100.186/handle/113462/139464]
专题	中国科学院近代物理研究所
通讯作者	Mao, Aihong; Wang, Bing
作者单位	1.Natl Inst Quantum & Radiol Sci & Technol, Natl Inst Radiol Sci, Chiba, Japan 2.Gansu Prov Acad Inst Med Res, Lanzhou 730050, Peoples R China 3.Chinese Acad Sci, Inst Modern Phys, Lanzhou, Peoples R China
推荐引用方式 GB/T 7714	Mao, Aihong,Sun, Chao,Katsube, Takanori,et al. A Minireview on Gastrointestinal Microbiota and Radiosusceptibility[J]. DOSE-RESPONSE,2020,18(4):11.
APA	Mao, Aihong,Sun, Chao,Katsube, Takanori,&Wang, Bing.(2020).A Minireview on Gastrointestinal Microbiota and Radiosusceptibility.DOSE-RESPONSE,18(4),11.
MLA	Mao, Aihong,et al."A Minireview on Gastrointestinal Microbiota and Radiosusceptibility".DOSE-RESPONSE 18.4(2020):11.