Guiqi Baizhu Decoction Alleviates Radiation Inflammation in Rats by Modulating the Composition of the Gut Microbiota

doi:10.1155/2020/9017854

	Guiqi Baizhu Decoction Alleviates Radiation Inflammation in Rats by Modulating the Composition of the Gut Microbiota
	Zhang, Li-Ying 4; Zhou, Ting 4; Zhang, Yi-Ming 4; Xu, Xiao-Min 4; Li, Yang-Yang 4; Wei, Kong-Xi 4; He, Jin-Peng 1,2; Ding, Nan 1,2; Zhou, Heng 1,2; Liu, Yong-Qi 3,4
刊名	EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
	2020-10-20
卷号	2020 页码:13
ISSN号	1741-427X
DOI	10.1155/2020/9017854
通讯作者	Liu, Yong-Qi(liuyongqi73@163.com)
英文摘要	The gut microbiota is important in metabolism and immune modulation, and compositional disruption of the gut microbiota population is closely associated with inflammation caused by ionizing radiation (IR). Guiqi Baizhu decoction (GQBZD) is a medicinal compound used in traditional Chinese medicine with anti-inflammatory and antioxidation effects, especially in the process of radiotherapy. However, the effect of GQBZD on reducing the damage to the normal immune system in radiotherapy remains unclear. Here, we show that GQBZD reduces body weights, water intake, food intake, diarrhea level and quality of life score, and inflammation and enhances immunity function in rats treated with X-ray radiation. Meanwhile, our data indicate that GQBZD not only reverses IR-induced gut dysbiosis as indicated change of alpha-diversity and beta-diversity of microbiota, the composition of Desulfovibrio, Bacteroides, and Parabacteroides, except for Roseburia and Lachnoclostridium, but also maintains intestinal barrier integrity and promoting the formation of short-chain fatty acids (SCFAs). GQBZD can also reduce the level of phosphorylation P65 (p-P65). Our results demonstrate that GQBZD can significantly alleviate the inflammatory responses and improve the immune damage against IR, and may be used as prebiotic agents to prevent gut dysbiosis and radiation-related metabolic disorders in radiotherapy.
资助项目	National Natural Science Foundation of China[82004094] ; National Natural Science Foundation of China[81973595] ; Open Fund of Key Laboratory of Molecular Medicine and Traditional Chinese Medicine Prevention and Treatment for Major Diseases for Colleges and Universities in Gansu Province[FZYX14-4] ; Open Fund of Key Laboratory of Molecular Medicine and Traditional Chinese Medicine Prevention and Treatment for Major Diseases for Colleges and Universities in Gansu Province[FZYX17-18-13] ; Collaborative Innovation Project of Chinese and Tibetan Medicine[XBXT2015-1] ; Project of Gansu Provincial Education Department[2015A-095] ; Open Fund of Key Laboratory of Dunhuang Medicine and Transformation at Provincial and Ministerial Level[DHYX19-13]
WOS关键词	OXIDATIVE STRESS
WOS研究方向	Integrative & Complementary Medicine
语种	英语
出版者	HINDAWI LTD
WOS记录号	WOS:000591545600003
资助机构	National Natural Science Foundation of China ; Open Fund of Key Laboratory of Molecular Medicine and Traditional Chinese Medicine Prevention and Treatment for Major Diseases for Colleges and Universities in Gansu Province ; Collaborative Innovation Project of Chinese and Tibetan Medicine ; Project of Gansu Provincial Education Department ; Open Fund of Key Laboratory of Dunhuang Medicine and Transformation at Provincial and Ministerial Level
内容类型	期刊论文
源URL	[http://119.78.100.186/handle/113462/139455]
专题	中国科学院近代物理研究所
通讯作者	Liu, Yong-Qi
作者单位	1.Chinese Acad Sci, Key Lab Space Radiobiol Gansu Prov, Inst Modern Phys, Lanzhou 730000, Peoples R China 2.Chinese Acad Sci, Key Lab Heavy Ion Radiat Biol & Med, Inst Modern Phys, Lanzhou 730000, Peoples R China 3.Gansu Univ Chinese Med, Key Lab Dunhuang Med & Transformat Prov & Ministe, Lanzhou 730000, Peoples R China 4.Gansu Univ Chinese Med, Prov Level Key Lab Mol Med Major Dis & Prevent &, Lanzhou 730000, Peoples R China
推荐引用方式 GB/T 7714	Zhang, Li-Ying,Zhou, Ting,Zhang, Yi-Ming,et al. Guiqi Baizhu Decoction Alleviates Radiation Inflammation in Rats by Modulating the Composition of the Gut Microbiota[J]. EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE,2020,2020:13.
APA	Zhang, Li-Ying.,Zhou, Ting.,Zhang, Yi-Ming.,Xu, Xiao-Min.,Li, Yang-Yang.,...&Liu, Yong-Qi.(2020).Guiqi Baizhu Decoction Alleviates Radiation Inflammation in Rats by Modulating the Composition of the Gut Microbiota.EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE,2020,13.
MLA	Zhang, Li-Ying,et al."Guiqi Baizhu Decoction Alleviates Radiation Inflammation in Rats by Modulating the Composition of the Gut Microbiota".EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE 2020(2020):13.