Adjuvant Radiotherapy of Involved Field versus Elective Lymph Node in Patients with Operable Esophageal Squamous Cell Cancer: A Single Institution Prospective Randomized Controlled Study

doi:10.7150/jca.50108

	Adjuvant Radiotherapy of Involved Field versus Elective Lymph Node in Patients with Operable Esophageal Squamous Cell Cancer: A Single Institution Prospective Randomized Controlled Study
	Liu, Ruifeng 1,2,3; Zhang, Xueliang 4; Zhang, Qiuning 1,2,3; Luo, Hongtao 1; Wei, Shihong 4; Liu, Tingting 4; Sun, Shilong 1,2,3; Liu, Zhiqiang 1,2,3; Li, Zheng 1,2,3; Tian, Jinhui 5
刊名	JOURNAL OF CANCER
	2021
卷号	12 期号:11 页码:3180-3189
关键词	esophageal cancer lymph node radiotherapy clinical outcomes adjuvant treatment
ISSN号	1837-9664
DOI	10.7150/jca.50108
通讯作者	Wang, Xiaohu(xhwang@impcas.ac.cn)
英文摘要	Background: To evaluate locoregional failure and its impact on survival by comparing involved field irradiation (IFI) with elective lymph node irradiation (ENI) for patients with esophageal squamous cell cancer who underwent post-operative radiotherapy. Methods and Materials: The enrolled patients were randomized allocated to IFI or ENI group. CTV of IFI was generated according to pre-operative primary tumor location and post-operative pathological characters and positive LNs regions. CTV of ENI was generated according to pre-operative tumor position to administer selective lymph node irradiation. Radiotherapy planning was delivered using either 3D-CRT or IMRT. Results: A total of 57 patients were enrolled, 28 patients in ENI group and 29 patients in IFI group. There were not statistical differences between two groups in baseline (p>0.05). The initial locoregional failure rate was 17.9 % in ENI arm and 20.7% in IFI arm respectively (p=0.085). The 1-, 3-, and 5-year Progression-free Survival (PFS) were 63.2, 43.5, and 21.8 % in ENI arm versus 78.2, 60.1, and 55.1% in IFI arm (p=0.038). The 1-, 3-, and 5-year overall survival (OS) were 78.6, 46.9, and 23.5 % in ENI arm versus 72.9, 59.7, and 54.3 % in IFI arm (p=0.06). Acute radiation pneumonitis (p=0.005) and hematological toxicities (p=0.029) also showed statistical differences between groups, ENI arm was more than IFI arm. Conclusions: The results indicated that IFI tended to improve survival and reduce toxicities for patients with operative ESCC and did not increase locoregional failure compared to ENI. It is thus suggested that IFI for ESCC PORT is worthy of clinical recommendation and further study.
资助项目	Talent innovation and venture project of Lanzhou city[2017-RC-23] ; Talent innovation and venture project of Lanzhou city[2020-RC-113] ; Key R&D Program of Science and Technology Department of Gansu Province[20YF8FA116] ; Gansu provincial healthcare industry science research project ; National key Research and Development Project of China[2016YFC0105706]
WOS研究方向	Oncology
语种	英语
出版者	IVYSPRING INT PUBL
WOS记录号	WOS:000637324800008
资助机构	Talent innovation and venture project of Lanzhou city ; Key R&D Program of Science and Technology Department of Gansu Province ; Gansu provincial healthcare industry science research project ; National key Research and Development Project of China
内容类型	期刊论文
源URL	[http://119.78.100.186/handle/113462/137586]
专题	中国科学院近代物理研究所
通讯作者	Wang, Xiaohu
作者单位	1.Chinese Acad Sci, Inst Modern Phys, Lanzhou 730000, Peoples R China 2.Lanzhou Heavy Ion Hosp, Lanzhou, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 4.Gansu Prov Canc Hosp, Lanzhou 730050, Peoples R China 5.Lanzhou Univ, Ctr Evidence Based Med, Lanzhou 730000, Peoples R China
推荐引用方式 GB/T 7714	Liu, Ruifeng,Zhang, Xueliang,Zhang, Qiuning,et al. Adjuvant Radiotherapy of Involved Field versus Elective Lymph Node in Patients with Operable Esophageal Squamous Cell Cancer: A Single Institution Prospective Randomized Controlled Study[J]. JOURNAL OF CANCER,2021,12(11):3180-3189.
APA	Liu, Ruifeng.,Zhang, Xueliang.,Zhang, Qiuning.,Luo, Hongtao.,Wei, Shihong.,...&Wang, Xiaohu.(2021).Adjuvant Radiotherapy of Involved Field versus Elective Lymph Node in Patients with Operable Esophageal Squamous Cell Cancer: A Single Institution Prospective Randomized Controlled Study.JOURNAL OF CANCER,12(11),3180-3189.
MLA	Liu, Ruifeng,et al."Adjuvant Radiotherapy of Involved Field versus Elective Lymph Node in Patients with Operable Esophageal Squamous Cell Cancer: A Single Institution Prospective Randomized Controlled Study".JOURNAL OF CANCER 12.11(2021):3180-3189.